5108-96-3 Usage
Description
Ammonium 1-pyrrolidinedithiocarbamate, also known as Ammonium pyrrolidinedithiocarbamate (APDC), is a metal chelating compound with potent and reversible inhibition of nuclear factor κB (NF-κB) activation. It exhibits antioxidant properties and is effective in inhibiting apoptosis in various cell types, including lymphocytes, neurons, and vascular endothelial cells. APDC is characterized by its pale yellow crystalline solid appearance.
Uses
Ammonium 1-pyrrolidinedithiocarbamate is used as a chelating agent for the preconcentration of trace metals from solution due to its ability to bind with metal ions.
Used in Pharmaceutical Applications:
Ammonium 1-pyrrolidinedithiocarbamate is used as an NF-κB inhibitor for its various therapeutic applications, including:
1. Inhibiting NF-κB mobilization and TNF (tumor necrosis factor) production in human monocytes, which can be beneficial in treating inflammatory conditions.
2. Reducing neutrophil activity in rats, which may help in managing inflammatory responses.
3. Preventing Ca2+ influx in adriamycin (ADR)-treated podocytes, potentially aiding in the treatment of kidney-related diseases.
4. Abolishing the microRNA-146a promoter luciferase reporter activity in human brain cells, which could have implications in neurological disorders.
Used in Cellular Research:
Ammonium 1-pyrrolidinedithiocarbamate is used as a tool in cellular research to:
1. Induce apoptosis in rat smooth muscle cells, which can provide insights into cell death mechanisms.
2. Inhibit apoptosis in leukemia HL-60 cells, offering potential applications in cancer research and treatment.
3. Prevent the induction of nitric oxide synthetase by inhibiting the translation of NOS mRNA, which may have implications in understanding and treating various diseases associated with nitric oxide dysregulation.
Biochem/physiol Actions
Prevents induction of nitric oxide synthetase by inhibiting translation of NOS mRNA; induces apoptosis in rat smooth muscle cells and inhibits apoptosis in leukemia HL-60 cells.
Purification Methods
Purify the salt by recrystallising twice by dissolving in MeOH and adding Et2O. It has also been purified by recrystallisation from EtOH. It is used for the precipitation of As, Bi, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Su, V and Zn from acidic solutions [Kinrade & van Loon Anal Chem 46 1894 1974]. The ethyl ester has b 87-89o/0.01mm. [Synthesis and Polarography: Kitagawa & Taku Bull Chem Soc Jpn 64 2151 1973, Malissa & Sch.ffmann Mikrochim Acta 187 1955, Beilstein 20 III/IV 195, 20/1 V 331.]
Check Digit Verification of cas no
The CAS Registry Mumber 5108-96-3 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,1,0 and 8 respectively; the second part has 2 digits, 9 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 5108-96:
(6*5)+(5*1)+(4*0)+(3*8)+(2*9)+(1*6)=83
83 % 10 = 3
So 5108-96-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H9N.CH3NS2.H3N/c1-2-4-5-3-1;2-1(3)4;/h5H,1-4H2;(H3,2,3,4);1H3
5108-96-3Relevant articles and documents
Tin(IV) complexes of pyrrolidinedithiocarbamate: Synthesis, characterisation and antifungal activity
Menezes,Vieira,De Lima,Porto,Cortes,Ardisson,Albrecht-Schmitt
, p. 1277 - 1282 (2005)
The reaction of ammonium pyrrolidinedithiocarbamate, [NH4{S 2CN(CH2)4}], with SnCl2, [Sn(C 6H5)2Cl2], [Sn(C6H 5)3Cl], [Sn(C4H9)2Cl 2] and [Sn(C6H11)3Cl] produced in good yield the compounds [Sn{S2CN(CH2)4} 2Cl2] (1), [Sn{S2CN(CH2) 4}2Ph2] (2), [Sn{S2CN(CH 2)4}Ph3] (3), [Sn{S2CN(CH 2)4}2n-Bu2] (4) and [Sn{S 2CN(CH2)4}Cy3] (5). The complexes were characterised by infrared, multinuclear NMR (1H, 13C{1H} and 119Sn{1H}) and 119Sn Moessbauer spectroscopies. In addition, the crystal structure of 4 was determined by X-ray crystallography. The in vitro antifungal activity of the tin(IV) complexes as well of the ligand was performed on human pathogenic fungi, Candida albicans, in concentrations of 0.025; 0.050; 0.100; 0.200; 0.400; 0.800; 1.600 and 3.200:mM. The microorganism presented resistance to the dithiocarbamate ligand and all tin(IV) complexes tested were actives. The highest activity was found for compounds 1 and 4.
SYNTHESIS OF AND STUDIES ON IRON(III) MONOTHIO- AND DITHIOCARBAMATES COMPLEXES
Wajda, Stanislaw,Piotrowska, Alina,Szmaj, Marianna,Zarzeczny, Augustyn
, p. 395 - 404 (2007/10/02)
Iron(III) monothio- and dithiocarbamates complexes, Fe(mtc)3, Fe(dtc)3 and Fe(dtc)2X have been synthesized and their Moessbauer, IR and electronic spectroscopy and magnetic measurements have been carried out. complexes show anomalous magnetic behavior arising from 2T (low spin, S=1/26A (high spin, S=5/2) spin-equilibrium.The differences in ΔEQ values have been explained by distortions from D3 symmetry, due to the asymmetry of FeS3O3 core.
