51110-86-2

Basic information

• Product Name: 3-phenyl-1,2,4-benzotriazine 1-oxide
• Synonyms: 3-phenyl-1,2,4-benzotriazine 1-oxide
• CAS NO: 51110-86-2
• Molecular Weight: 223.234
• Mol File: 51110-86-2.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3-phenyl-1,2,4-benzotriazine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-phenyl-1,2,4-benzotriazine 1-oxide(51110-86-2)
• EPA Substance Registry System: 3-phenyl-1,2,4-benzotriazine 1-oxide(51110-86-2)

Safety Data

• Hazardous Substances Data: 51110-86-2(Hazardous Substances Data)

Upstream product

• 3493-72-9 N-(2-nitro-phenyl)-benzimidoyl chloride 
• 88-74-4 2-nitro-aniline 
• 5424-06-6 3-amino-1,2,4-benzotriazine 1-oxide 
• 67692-91-5 3-chloro-1,2,4-benzotriazine 1-oxide 
• 98-80-6 phenylboronic acid 
• 7722-84-1 dihydrogen peroxide 
• 64-19-7 acetic acid 
• 106987-24-0 N-(2-nitrophenyl)benzenecarboximidamide 
• 6299-90-7 3-phenylbenzo-1,2,4-triazine 

Relevant articles and documents

New and versatile syntheses of 3-alkyl- and 3-aryl-1,2,4-benzotriazine 1,4-dioxides: Preparation of the bioreductive cytotoxins SR 4895 and SR 4941

Palladium-mediated coupling of 3-chloro-1,2,4-benzotriazine 1-oxide with a variety of stannanes in the presence of Pd(PPh3)4 gives 3-alkyl derivatives in good yields. Suzuki reaction of the 3-chloro compound with phenylboronic acids gives 3-aryl-1,2,4-benzotriazine 1-oxides. Oxidation of 1-oxides with trifluoroperacetic acid gives the 1,4-dioxides. This method provides a better route to the potential anti-cancer agents SR 4895 and SR 4941.

Benzoazine mono-N-oxides and benzoazine 1,4 dioxides and compositions therefrom for the therapeutic use in cancer treatments

The present invention relates to a synergetistic composition comprising one or more benzoazine-mono-N-oxides, and one or more benzoazine 1,4 dioxides for use in cancer therapy. The invention also provides a range of novel 1,2,4 benzoazine-mono-N-oxides and related analogues. These can be used as potentiators of the cytotoxicity of existing anticancer drugs and therapies for cancer treatment.