67692-91-5

Basic information

• Product Name: 3-chloro-1,2,4-benzotriazine 1-oxide
• CAS NO: 67692-91-5
• Molecular Formula: C₇H₄ClN₃O
• Molecular Weight: 181.5792
• Mol File: 67692-91-5.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 392.2°C at 760 mmHg
• Flash Point: 191°C
• Density: 1.57g/cm³
• Vapor Pressure: 5.26E-06mmHg at 25°C
• Refractive Index: 1.716
• CAS DataBase Reference: 3-chloro-1,2,4-benzotriazine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-1,2,4-benzotriazine 1-oxide(67692-91-5)
• EPA Substance Registry System: 3-chloro-1,2,4-benzotriazine 1-oxide(67692-91-5)

Safety Data

• Hazardous Substances Data: 67692-91-5(Hazardous Substances Data)

Upstream product

• 5424-06-6 3-amino-1,2,4-benzotriazine 1-oxide 
• 27446-08-8 3-oxo-3,4-dihydrobenzo-1,2,4-triazine 1-oxide 
• 1493-27-2 ortho-nitrofluorobenzene 
• 3320-86-3 2-nitrophenyl isocyanate 
• 2273-04-3 1-(2-nitrophenyl)urea 
• 88-74-4 2-nitro-aniline 
• 27446-08-8 3-hydroxybenzo[e][1,2,4]triazine-1-oxide 
• 20028-80-2 SR 4330 

Downstream Products

• 94906-62-4 (1-oxy-benzo[1,2,4]triazin-3-yl)-phenethyl-amine 
• 91669-21-5 3-chlorobenzo[e][1,2,4]triazine 
• 5424-06-6 3-amino-1,2,4-benzotriazine 1-oxide 
• 84991-07-1 methyl 2-{4-[(1-oxide-1,2,4-benzotriazin-3-yl)oxy]phenoxy}propionate 
• 106321-20-4 3-(4-methoxy-phenyl)-benzo[e][1,2,4]triazine-1-oxide 
• 51110-86-2 3-phenyl-1,2,4-benzotriazine 1-oxide 
• 121745-82-2 N-phenyl-1,2,4-benzotriazin-3-amine 1-oxide 
• 77475-32-2 ethyl 2-(benzo[e][1,2,4]triazin-3-yl)acetate 
• 96583-60-7 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide 
• 1383844-70-9 (R)-3-((1-cyclohexylethyl)amino)benzo[e][1,2,4]triazine-1,4-dioxide 
• 1383844-69-6 3-((4-(tert-butyl)cyclohexyl)amino)benzo[e][1,2,4]triazine 1,4-dioxide 
• 916890-49-8 4-[4-(1-oxybenzo[1,2,4]triazin-3-ylamino)phenyl]piperazine-1-carboxylic acid tert-butyl ester 
• 906004-85-1 methyl 2-({[1-(1-oxido-1,2,4-benzotriazin-3-yl)-4-piperidinyl]acetyl}amino)benzoate 
• 906004-80-6 methyl 2-({[1-(1-oxido-1,2,4-benzotriazin-3-yl)-4-piperidinyl]carbonyl}amino)benzoate 

Relevant articles and documents

3-Substituted Benzo[ e][1,2,4]triazines: Synthesis and Electronic Effects of the C(3) Substituent

A series of 19 structurally diverse C(3)-substituted derivatives of benzo[e][1,2,4]triazine were synthesized from 3-chloro- (1c) and 3-iodobenzo[e][1,2,4]triazine (1d) obtained in three steps from 2-nitroaniline in 37-55% yields. Nucleophilic aromatic substitution and metal-catalyzed (Pd, Cu) reactions led to functional derivatives that include alkyl (C5H11), (het)aryl (Ph, 2-thienyl, ferrocenyl), ArCC, amine (NHPh and morpholine), PO(OEt)2, sulfanyl (SBu-t), alkoxide (OEt, OMe), and CN. The synthesis of C(3)-CF3 derivative 1g via the Ruppert reaction with 1d and its 1-oxide analogue 2d led to the substitution followed by formal addition of HCF3 to the C?N bond. Pd-catalyzed carbonylation reactions of 1d and 2d did not give the corresponding C(3)-carboxylic acids. Therefore, acid 1f was obtained through hydrolysis of the CN. The substituent effect on the electronic structure of the benzo[e][1,2,4]triazine ring was investigated by spectroscopic methods (UV-vis and NMR) augmented with density functional theory calculations. Results show significant effect of the C(3) substituent on the (1) transition energy and good correlation of the 1H NMR chemical shift with the substituent constant σp. Molecular and crystal structures of six derivatives were established with the single-crystal X-ray diffraction method, and the substituent impact on the molecular geometry was investigated.

Application of Suzuki–Miyaura and Buchwald–Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine

Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-position, 6-position, and 7-position.

Synthesis, structure and hypoxic cytotoxicity of 3-amino-1,2,4- benzotriazine-1,4-dioxide derivatives

A series of novel 3-amino-1,2,4-benzotriazine-1,4-dioxide derivatives were synthesized and screened for their in vitro cytotoxicity against promyelocyte leukemia HL-60, androgen-independent prostate tumor PC3, hepatocellular carcinoma Bel-7402, human esop