96583-60-7

Basic information

• Product Name: 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide
• Synonyms: 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide
• CAS NO: 96583-60-7
• Molecular Weight: 268.232
• Mol File: 96583-60-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide(96583-60-7)
• EPA Substance Registry System: 3-(4-nitrophenyl)-1,2,4-benzotriazine 1-oxide(96583-60-7)

Safety Data

• Hazardous Substances Data: 96583-60-7(Hazardous Substances Data)

Upstream product

• 98555-53-4 3-bromo-1,2,4-benzotriazine 1-oxide 
• 24067-17-2 4-nitrophenylboronic acid 
• 67692-91-5 3-chloro-1,2,4-benzotriazine 1-oxide 
• 27446-08-8 3-hydroxybenzo[e][1,2,4]triazine-1-oxide 
• 5424-06-6 3-amino-1,2,4-benzotriazine 1-oxide 
• 88-74-4 2-nitro-aniline 
• 6165-65-7 3-(4-nitrophenyl)-1,5-diphenylformazan 
• 99137-11-8 4-nitro-N-(2-nitro-phenyl)-benzimidoyl chloride 
• 106987-23-9 4-nitro-N-(2-nitro-phenyl)-benzamidine 

Downstream Products

• 1401236-55-2 3-(4-nitrophenyl)-1,2,4-benzotriazine 1,4-dioxide 
• 100382-38-5 4-benzo[e][1,2,4]triazin-3-yl-aniline 

Relevant articles and documents

Application of Suzuki–Miyaura and Buchwald–Hartwig Cross-coupling Reactions to the Preparation of Substituted 1,2,4-Benzotriazine 1-Oxides Related to the Antitumor Agent Tirapazamine

Many 1,2,4-benzotriazine 1,4-dioxides display the ability to selectively kill the oxygen-poor cells found in solid tumors. As a result, there is a desire for synthetic routes that afford access to substituted 1,2,4-benzotriazine 1-oxides that can be used as direct precursors in the synthesis of 1,2,4-benzotriazine 1,4-dioxides. Here we describe the use of Suzuki–Miyaura and Buchwald–Hartwig cross-coupling reactions for the construction of various 1,2,4-benzotriazine 1-oxide analogs bearing substituents at the 3-position, 6-position, and 7-position.