51136-18-6 Usage
Description
1H-Benzo[g]indole-3-carboxaldehyde is an organic compound that serves as a key intermediate in the synthesis of various biologically active molecules, particularly those with potential applications in the pharmaceutical and chemical industries. It is characterized by its unique chemical structure, which features a benzene ring fused to an indole ring, with a formyl group attached to the indole nitrogen.
Uses
Used in Pharmaceutical Industry:
1H-Benzo[g]indole-3-carboxaldehyde is used as a reactant for the preparation of tryptophan dioxygenase inhibitors, which are pyridyl-ethenyl-indoles. These compounds have potential applications as anticancer immunomodulators, making them valuable in the development of novel therapeutic strategies for cancer treatment.
Used in Chemical Industry:
In the chemical industry, 1H-Benzo[g]indole-3-carboxaldehyde can be utilized as a building block for the synthesis of a wide range of complex organic molecules, including those with potential applications in materials science, agrochemistry, and other areas. Its unique structure and reactivity make it a versatile starting material for the development of new compounds with diverse properties and functions.
Check Digit Verification of cas no
The CAS Registry Mumber 51136-18-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,1,1,3 and 6 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 51136-18:
(7*5)+(6*1)+(5*1)+(4*3)+(3*6)+(2*1)+(1*8)=86
86 % 10 = 6
So 51136-18-6 is a valid CAS Registry Number.
51136-18-6Relevant articles and documents
BENZINDOLES. 21. NITRATION OF 3-FORMYL- AND 3-FORMYLBENZINDOLES
Zhilina, O.D.,Shagalov,L. B.,Vasil'ev, A. M.,Suvorov, N. N.
, p. 735 - 740 (1980)
It was established that products of monosubstitution of 4-nitro- and 7-nitro-3-formylbenzindoles and products of disubstitution of 4,8-dinitro- and 7,8-dinitro-3-formylbenzindoles are formed in low yields in the nitration of 3-formylbenzindole with sodium nitrate in concentrated sulfuric acid.Similar nitration of 3-formylbenzindole leads to 9-nitro- and 5,6-dinitro-3-formylbenzindoles.The 3-formylnitrobenzindoles obtained were converted to nitrovinyl derivatives by condensation with nitromethane.
The synthesis and evaluation of benzannelated-azatoxins: The benzazatoxins
Miller, Thomas A.,Vachaspati, Prakash R.,Labroli, Marc A.,Thompson, Charles D.,Bulman, Amanda L.,Macdonald, Timothy L.
, p. 1065 - 1070 (2007/10/03)
The synthesis and evaluation of azatoxin congeners possessing annealed aromatic frameworks are described. The compounds were evaluated for their abilities to affect topoisomerase II inhibition through the stabilization of 'cleavable complex' and for the inhibition of tubulin polymerization using purified bovine brain tubulin.
