51209-75-7Relevant articles and documents
S-nitrosocysteine and cystine from reaction of cysteine with nitrous acid. A kinetic investigation.
Grossi, Loris,Montevecchi, Pier Carlo
, p. 8625 - 8630 (2007/10/03)
The formation of the S-nitrosocysteine (CySNO) in aqueous solution starting from cysteine (CySH) and sodium nitrite is shown to strongly depend on the pH. Experiments conducted within the pH range 0.5-7.0 show that at pH below 3.5 the NO+ (or H2NO 2 +) is
NO-Group transfer (transnitrosation) between S-nitrosothiols and thiols. Part 2
Barnett, D.Jonathan,Rios, Ana,Williams, D. Lyn H.
, p. 1279 - 1282 (2007/10/03)
The kinetics of NO-group transfer have been measured for the reaction between a nitrosothiol (HOCH2CH2SNO) and nine thiols, mostly based on the cysteine structure.The reaction is second-order and there is evidence for a steric effect for thiols containing 1,1-dimethyl substituents (penicillamine derivatives).Reaction occurs via the thiolate anion as shown by the pH-rate constant profile, and a full kinetic analysis for the reactions of two thiols (N-acetylcysteine and glutathione) is quantitatively in agreement with this mechanism.Variation of the nitrosothiol structure for reaction with N-acetylcysteine shows that electron-withdrawing substituents in the nitrosothiol promote reaction; there is a similarity with the corresponding reactions of alkyl nitrites.