51220-84-9

Basic information

• Product Name: METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE
• Synonyms: METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE
• CAS NO: 51220-84-9
• Molecular Formula: C₁₄H₂₁NO₄S
• Molecular Weight: 299.39
• Mol File: 51220-84-9.mol
• Article Data: 18

Chemical Properties

• Melting Point: 54-56,5°C
• Boiling Point: 411.1 °C at 760 mmHg
• Flash Point: 202.4 °C
• Appearance: /
• Density: 1.153 g/cm³
• Vapor Pressure: 5.72E-07mmHg at 25°C
• Refractive Index: 1.513
• CAS DataBase Reference: METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE(51220-84-9)
• EPA Substance Registry System: METHYL 4-METHYL-2-([(4-METHYLPHENYL)SULFONYL]AMINO)PENTANOATE(51220-84-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 51220-84-9(Hazardous Substances Data)

Usage

General Description

Methyl 4-methyl-2-[(4-methylphenyl)sulfonyl]amino)pentanoate is a compound that belongs to the class of sulfonamide compounds. It is characterized by a pentanoate chain with a methyl group and a sulfonamide group attached. This chemical is commonly used in medicinal and pharmaceutical research, especially in the development of potential drug candidates. Its structure and properties make it an important component in the design and synthesis of bioactive molecules, including potential treatments for various diseases and conditions. Due to its versatile nature, this compound is of interest to researchers and scientists in the field of drug discovery and development.

InChI:InChI=1/C14H21NO4S/c1-10(2)9-13(14(16)19-4)15-20(17,18)12-7-5-11(3)6-8-12/h5-8,10,13,15H,9H2,1-4H3

Upstream product

• 2666-93-5 (S)-Leu-OMe 
• 98-59-9 p-toluenesulfonyl chloride 
• 186581-53-3 diazomethane 
• 1220-80-0 (S)-4-methyl-2-(toluene-4-sulfonamido)pentanoic acid 
• 79-20-9 acetic acid methyl ester 
• 67368-40-5 4-methyl-2-{[(4-methylphenyl)sulphonyl]amino}pentanoic acid 
• 6322-53-8 leucine methyl ester hydrochloride 
• 18869-43-7 DL-leucine methyl ester 
• 67-56-1 methanol 
• 61-90-5 L-leucine 
• 68305-83-9 N-Tosyl-DL-leucin-methylester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 

Downstream Products

• 51220-84-9 (S)-methyl 4-methyl-2-(4-methylphenylsulfonamido)pentanoate 
• 1236362-43-8 (S)-methyl 2-(N-((R)-3-(tert-butyldimethylsilyloxy)-2-(2-nitrophenylamino)propyl)-4-methylphenylsulfonamido)-4-methylpentanoate 
• 932725-32-1 (S)-3-isobutyl-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydro-benzo[f][1,4]oxazepine 
• 1303530-20-2 N-(2-bromobenzyl)-N-(1-hydroxymethyl-3-methylbutyl)-4-methylbenzenesulfonamide 
• 1303530-12-2 2-[(2-bromobenzyl)(toluene-4-sulfonyl)amino]-4-methylpentanoic acid methyl ester 
• 1365553-86-1 2,2-dimethyl-propionic acid 4-[(1-hydroxymethyl-3-methyl-butyl)-(toluene-4-sulfonyl)-amino]-methyl-7-methyl-cyclohepta-1,3,6-trienyl ester 
• 1208311-32-3 (S)-3-isobutyl-8-methoxy-4-tosyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine 
• 1208311-07-2 (S)-N-(2-(benzyloxy)-4-methoxybenzyl)-N-(1-hydroxy-4-methylpentan-2-yl)-4-methylbenzenesulfonamide 
• 220324-30-1 N-((S)-1-Formyl-3-methyl-butyl)-4-methyl-benzenesulfonamide 

Relevant articles and documents

Nitroxyl Catalysts for Six-Membered Ring Bromolactonization and Intermolecular Bromoesterification of Alkenes with Carboxylic Acids

We developed a nitroxyl-catalyzed bromoesterification of alkenes with bromo reagents, which includes a six-membered ring bromolactonization of alkenyl carboxylic acids catalyzed by AZADO as the nitroxyl radical catalyst, and an intermolecular bromoesterification of alkenes with carboxylic acids using NMO as the N-oxide catalyst. We also accomplished a remote diastereoselective bromohydroxylation via an AZADO-catalyzed six-membered ring bromolactonization and a subsequent ring cleavage reaction with alkylamines to furnish ?-bromo-δ-hydroxy amides with high diastereoselectivity.

General Strategy for Stereoselective Synthesis of β- N-Glycosyl Sulfonamides via Palladium-Catalyzed Glycosylation

A highly efficient and mild glycosylation reaction between 3,4-O-carbonate glycal and N-tosyl functionalized aliphatic and aromatic amines via palladium-catalyzed decarboxylative allylation is disclosed. A wide range of highly functionalized 2,3-unsaturat

Chemoselective Intramolecular Functionalization of Methyl Groups in Nonconstrained Molecules Promoted by N-Iodosulfonamides

Mechanistic evidence observed in Hofmann-L?ffler-Freytag-type reactions has been crucial to achieve the chemoselective functionalization of methyl groups under mild conditions. Radical-mediated methyl iodination and subsequent oxidative deiodination are the key steps in this functionalization, where iodine chemistry has a pivotal role on the formation of the C-N bond. The concepts of single hydrogen atom transfer (SHAT) and multiple hydrogen atom transfer (MHAT) are introduced to describe the observed chemoselectivity. (Chemical Equation Presented).