514-78-3

Basic information

• Product Name: Canthaxanthin
• Synonyms: 4,4'-DIKETO-BETA-CAROTENE;4',4-DIOXO-B-CAROTENE;FOOD ORANGE 8;E 161 G;BETA,BETA-CAROTENE-4,4'-DIONE;BETA,BETA'-CAROTIN-4,4'-DIONE;B,B-CAROTENE-4,4'DIONE;CANTHAXANTHIN
• CAS NO: 514-78-3
• Molecular Formula: C40H52O2
• Molecular Weight: 564.84
• EINECS: 208-187-2
• Product Categories: Carotenoids;Organics;Intermediates & Fine Chemicals;Pharmaceuticals;Plant extracts;Herb extract
• Mol File: 514-78-3.mol
• Article Data: 37

Chemical Properties

• Melting Point: 217～218℃
• Boiling Point: 717 °C at 760 mmHg
• Flash Point: 253.9 °C
• Appearance: purple to reddish-violet
• Density: 1.003 g/cm³
• Vapor Pressure: 2.09E-20mmHg at 25°C
• Refractive Index: 1.575
• Storage Temp.: 0-6°C
• Solubility: Chloroform (Slightly)
• Stability: Light Sensitive
• Merck: 13,1758
• BRN: 1898520
• CAS DataBase Reference: Canthaxanthin(CAS DataBase Reference)
• NIST Chemistry Reference: Canthaxanthin(514-78-3)
• EPA Substance Registry System: Canthaxanthin(514-78-3)

Safety Data

• WGK Germany: nwg
• RTECS: FI0330000
• Hazardous Substances Data: 514-78-3(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 514-78-3 differently. You can refer to the following data:
1. Oral suntanning agent
2. Antioxidant immune to promote
3. Permissible color additive for food and drugs (exempt from certification): Fed. Regist. 34, no. 5 (Jan. 8, 1969). Oral suntanning agent.
4. Canthaxanthin is a synthetic red colorant that is the carotenoid of most intense red color. it is available in oil-soluble, oil-dispersible, and water-dispersible forms. it has fair ph, heat, light, and chemical stability with a low tinctorial strength. unlike the carotenoids beta- carotene and beta-apo-8-carotenal, it does not possess vitamin a activity. maximum usage level is 66 ppm. uses include carbonated soft drinks, salad dressing, and spaghetti sauce.

Definition

ChEBI: A carotenone that consists of beta,beta-carotene bearing two oxo substituents at positions 4 and 4'.

Brand name

Apotrin;Phenoro.

World Health Organization (WHO)

Canthaxanthin, a naturally-occurring carotenoid with a deep redorange colour, is widely used as a food colouring agent. Since the mid-1970s it has been included in oral 'artificial suntan' preparations. It is also available in preparations used in the treatment of certain photodermatoses. By the mid-1980s its use in such preparations had been associated with the accumulation of crystalline deposits in the retina. Reported functional changes relating to dark adaptation have been of marginal clinical significance and largely reversible. Nevertheless, this has led to the withdrawal of artificial suntan preparations containing canthaxanthin by several regulatory authorities. Preparations for treatment of photodermatoses remain available in some but not all of these countries.

General Description

Canthaxanthin (red diketocarotenoid or 4, 4′-diketo-β-carotene), is a common xanthophyll found naturally in microorganisms and marine organisms, as well as in certain animals. It acts as an antioxidant in living organisms. The potential antioxidant activity of canthaxanthin is due to the presence of conjugated double bonds in its structure. It finds applications in various fields including poultry, fishery, cosmetics, medicine, and pharmaceuticals. In food industries, canthaxanthin can be used as a coloring agent.

Hazard

Oral intake may cause loss of night vision.

Safety Profile

When heated to decomposition it emits acrid smoke and irritating fumes.

Purification Methods

Purify canthaxanthin by chromatography on a column of deactivated alumina or magnesium oxide, or on a thin layer plate of silica gel G (M

Properties and Applications

yellow light pink to red yellow light.

InChI:InChI=1/C40H52O2/c1-29(17-13-19-31(3)21-23-35-33(5)37(41)25-27-39(35,7)8)15-11-12-16-30(2)18-14-20-32(4)22-24-36-34(6)38(42)26-28-40(36,9)10/h11-24H,25-28H2,1-10H3/b12-11+,17-13-,18-14+,23-21-,24-22+,29-15-,30-16+,31-19-,32-20+

Synthetic route

beta-carotene (7235-40-7) → canthaxanthin (514-78-3)

Conditions	Yield
With cerium(IV) oxide; sulfuric acid; potassium iodide In dichloromethane; water at 0℃; under 760.051 Torr; for 2.5h; Reagent/catalyst; Temperature; UV-irradiation;	99.5%
With sulfuric acid; copper(II) sulfate; potassium iodide In dichloromethane; water at -5 - 45℃; under 760.051 Torr; for 4h; Temperature; Reagent/catalyst; Green chemistry;	98.05%
With dihydrogen peroxide; potassium iodide; lithium hydroxide In dichloromethane; water at -5 - 45℃; under 760.051 Torr; for 5.5h; Catalytic behavior; Temperature; Reagent/catalyst; Green chemistry;	98.05%

β-carotene (161023-01-4) → canthaxanthin (514-78-3)

Conditions	Yield
With Aminoiminomethanesulfinic acid In dichloromethane; water at 20 - 40℃; for 17h; Temperature; Industrial scale;	94.66%

(2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial (5056-17-7) + C19H31O4P → canthaxanthin (514-78-3)

Conditions	Yield
With sodium t-butanolate In dimethyl sulfoxide; toluene at -20℃; for 6h; Reagent/catalyst; Temperature; Solvent;	92.1%

7,8,7',8'-tetrahydro-8,8'-dimethoxy-canthaxanthin → canthaxanthin (514-78-3)

Conditions	Yield
With sodium hydroxide; hydrogen bromide In n-heptane; dichloromethane	82%

(2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial (5056-17-7) + (2E,4E)-<5-(2,6,6-trimethyl-3-oxo-1-cyclohexen-1-yl)-3-methyl-2,4-pentadien-1-yl>triphenylphosphonium bromide (63184-93-0) → canthaxanthin (514-78-3)

Conditions	Yield
With sodium methylate In methanol; dichloromethane at -10℃; for 1h;	78%

aqueous sodium chloride + 3-methyl-5-(2,6,6-trimethyl-3-oxocyclohex-1-enyl)-2,4-pentadienylphosphonic acid, diethyl ester + (2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial (5056-17-7) + benzene (71-43-2) → canthaxanthin (514-78-3)

Conditions	Yield
With potassium tert-butylate In tetrahydrofuran; chloroform	52%

N-Bromosuccinimide (128-08-5) + 4-Phenylmorpholine (92-53-5) + ethanol (64-17-5) + chloroform (67-66-3) + beta-carotene (7235-40-7) → canthaxanthin (514-78-3)

Conditions	Yield
at -18℃; Reaktion ueber mehrere Stufen;

5,6;5',6'-diseco-β,β-carotene-4,6,4',6'-tetraone (105819-60-1) → canthaxanthin (514-78-3)

Conditions	Yield
With potassium hydroxide; benzene

4',5'-didehydro-4,5'-retro-β,β-carotene (3297-24-3, 16962-72-4, 71629-79-3) → canthaxanthin (514-78-3)

Conditions	Yield
(i) NBS, AcOH, PhNMe2, (ii) KOH, MeOH, benzene; Multistep reaction;

all-trans canthaxanthin radical cation → canthaxanthin (514-78-3)

Conditions	Yield
With TX-100 In water Rate constant; Irradiation;
With puerarin dianion In methanol; chloroform at 25℃; Thermodynamic data; Kinetics; Reagent/catalyst;

lycopene (502-65-8) + all-trans canthaxanthin radical cation → canthaxanthin (514-78-3) + lycopene radical cation

Conditions	Yield
In benzene Rate constant; pulse radiolysis;

beta-carotene (7235-40-7) + all-trans canthaxanthin radical cation → canthaxanthin (514-78-3) + all-trans β-carotene radical cation

Conditions	Yield
In benzene Rate constant; pulse radiolysis;

β,β-carotene-4,4'-diol → canthaxanthin (514-78-3)

Conditions	Yield
With 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide

5,6;5',6'-diseco-β,β-carotene-4,6,4',6'-tetraone (105819-60-1) + benzene (71-43-2) + methanol. KOH-solution → canthaxanthin (514-78-3)

N-Bromosuccinimide (128-08-5) + ethanol (64-17-5) + chloroform (67-66-3) + beta-carotene (7235-40-7) + 1-ethyl-morpholine → canthaxanthin (514-78-3)

Conditions	Yield
Reaktion ueber mehrere Stufen;

chloroform (67-66-3) + 1,2,3,4-tetrahydro-1-naphthyl hydroperoxide (771-29-9) + beta-carotene (7235-40-7) → canthaxanthin (514-78-3) + 3',4'-didehydro-β,β-caroten-4-one (991-90-2) + β,β-carotene-4,4'-diol + β,β-caroten-4-one

4'-ethoxy-β,β-caroten-4-one → canthaxanthin (514-78-3) + 4'-ethoxy-3',4'-didehydro-β,β-caroten-4-one

Conditions	Yield
With N-Bromosuccinimide; chloroform beim anschliessenden Behandeln mit 4-Phenyl-morpholin;

C40H51O2(1+) → canthaxanthin (514-78-3) + ascorbic acid radical

Conditions	Yield
With triton X100; ascorbic acid In methanol Rate constant; pH 7;

2,4,4-Trimethyl-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-cyclohex-1-enyl)-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-cyclohex-2-enyl-oxonium → 9-cis-β,β-caroten-4,4'-diol + canthaxanthin (514-78-3)

Conditions	Yield
With water In acetone

C40H56(2+) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 4 steps 1: 18 percent / H2O / acetone 2: NaBH4 3: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 4: H2O / acetone View Scheme
Multi-step reaction with 6 steps 1: 18 percent / H2O / acetone 2: NaBH4 3: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 4: 19 percent / acetone 5: H2O / acetone View Scheme

2,4,4-Trimethyl-3-[(1E,3E,5E,7E,9E,11E,13E,15E,17E)-3,7,12,16-tetramethyl-18-(2,6,6-trimethyl-cyclohex-1-enyl)-octadeca-1,3,5,7,9,11,13,15,17-nonaenyl]-cyclohex-2-enyl-oxonium → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: 19 percent / acetone 2: H2O / acetone View Scheme

4'-acetylthio-β,β-carotene (846539-06-8) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: H2O / acetone View Scheme

4'-hydroxy-β,β-caroten-4-one (106356-06-3, 125377-14-2, 125472-27-7, 2213-17-4) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 3 steps 1: NaBH4 2: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 3: H2O / acetone View Scheme
Multi-step reaction with 5 steps 1: NaBH4 2: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 3: 19 percent / acetone 4: H2O / acetone View Scheme

4,4'-diacetoxy-β,β-carotene (58540-69-5) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 2 steps 1: CF3COOH / CH2Cl2 / -10 °C 2: H2O / acetone View Scheme

isozeaxanthin (29065-03-0, 68538-97-6, 84142-78-9, 84518-15-0, 106037-10-9, 125472-26-6, 21940-25-0) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 5 steps 1: CF3SO3H / CH2Cl2 / -15 °C 2: 18 percent / H2O / acetone 3: NaBH4 4: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 5: H2O / acetone View Scheme
Multi-step reaction with 7 steps 1: CF3SO3H / CH2Cl2 / -15 °C 2: 18 percent / H2O / acetone 3: NaBH4 4: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 5: 19 percent / acetone 6: H2O / acetone View Scheme
Multi-step reaction with 2 steps 1: CF3COOH / CH2Cl2 / 0.17 h / -20 °C 2: H2O / acetone View Scheme

(E)-3-methylpent-2-en-4-yn-1-ol (6153-06-6) → canthaxanthin (514-78-3)

Conditions

Yield

Multi-step reaction with 6 steps 1: 92 percent / p-toluenesulfonic acid / 1.) 5 deg C, 2.) RT, 10 min 2: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h 3: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr 4: PBr3 / diethyl ether / 0.08 h / Ambient temperature 5: 69 percent / benzene / Heating 6: 78 percent / NaOCH3 / CH2Cl2; methanol / 1 h / -10 °C View Scheme

4-penten-3-one (1629-58-9) → canthaxanthin (514-78-3)

Conditions

Yield

Multi-step reaction with 8 steps 1: 1.) LDA / 1.) THF, hexane, -60 deg C, 90 min, 2.) a) 3 min, b) RT, 2 h 2: 85 percent / NaH / methanol / 3 h / Heating 3: 91 percent / p-toluenesulfonic acid / benzene / 3 h / Heating 4: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h 5: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr 6: PBr3 / diethyl ether / 0.08 h / Ambient temperature 7: 69 percent / benzene / Heating 8: 78 percent / NaOCH3 / CH2Cl2; methanol / 1 h / -10 °C View Scheme

2,2-dimethyl-5-oxo-heptanoic acid methyl ester (64095-45-0) → canthaxanthin (514-78-3)

Conditions

Yield

Multi-step reaction with 7 steps 1: 85 percent / NaH / methanol / 3 h / Heating 2: 91 percent / p-toluenesulfonic acid / benzene / 3 h / Heating 3: 1.) n-BuLi / 1.) ether, hexane, RT, 15 min, 2.) 22 deg C, 1 h 4: 72 percent / H2, potassium carbonate / Lindlar catalyst / toluene / 3 h / 20 °C / 760 Torr 5: PBr3 / diethyl ether / 0.08 h / Ambient temperature 6: 69 percent / benzene / Heating 7: 78 percent / NaOCH3 / CH2Cl2; methanol / 1 h / -10 °C View Scheme

alpha-ionone (127-41-3, 6901-97-9, 14398-36-8, 24190-29-2, 30685-95-1, 31798-12-6, 52340-45-1, 67529-94-6, 67529-95-7) → canthaxanthin (514-78-3)

Conditions	Yield
Multi-step reaction with 5 steps 1: 1.) sodium acetate, peracetic acid, 2.) NaOCH3 / 1.) dichloromethane, acetic acid, a) 15 deg C, 2,5 h, b) RT, 3 h, 2.) methanol, reflux, 3 h 2: tetrahydrofuran / 0.5 h / 10 °C 3: aluminum isopropoxide / acetone; CH2Cl2 / 5 h / Heating 4: CH2Cl2 / 1 h / Ambient temperature 5: 78 percent / NaOCH3 / CH2Cl2; methanol / 1 h / -10 °C View Scheme
Multi-step reaction with 6 steps 1: 1.) sodium acetate, peracetic acid, 2.) NaOCH3 / 1.) dichloromethane, acetic acid, a) 15 deg C, 2,5 h, b) RT, 3 h, 2.) methanol, reflux, 3 h 2: tetrahydrofuran / 0.5 h / 10 °C 3: aluminum isopropoxide / acetone; CH2Cl2 / 5 h / Heating 4: PBr3 / diethyl ether / 1 h / Ambient temperature 5: benzene / 1.5 h / Heating 6: 78 percent / NaOCH3 / CH2Cl2; methanol / 1 h / -10 °C View Scheme
Multi-step reaction with 6 steps 1.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h 2.1: sodium methylate / methanol / 3 h / Reflux 3.1: sodium methylate / toluene / 3.5 h 4.1: sodium ethanolate / ethanol / 25 °C / Inert atmosphere 5.1: potassium tert-butylate / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 5.5 h / Inert atmosphere 5.2: 2.58 h / -25 - 25 °C / Inert atmosphere 6.1: aluminum isopropoxide / acetone / 5 h / Reflux; Inert atmosphere 6.2: 10 h / 80 °C / Inert atmosphere View Scheme

canthaxanthin (514-78-3) + girard's reagent P (1126-58-5) → (GRP)2-canthaxanthin

Conditions	Yield
With hydrogenchloride In methanol; chloroform	34%

canthaxanthin (514-78-3) → 4'-thioxo-β,β-caroten-4-one

Conditions	Yield
With Lawessons reagent In benzene at 40℃; for 4h;	22%
With Lawessons reagent In carbon disulfide for 4h; Inert atmosphere; Reflux;

canthaxanthin (514-78-3) + (2E,4EZ)-N-(4-hexyloxyphenyl)-3-methylhexa-2,4-dienamide (1332483-19-8) → C37H49NO3 (1332483-31-4)

Conditions	Yield
With Hoveyda-Grubbs catalyst second generation In toluene at 20℃; for 24h; Inert atmosphere; diastereoselective reaction;	17%

canthaxanthin (514-78-3) → 4'-hydroxy-β,β-caroten-4-one (106356-06-3, 125377-14-2, 125472-27-7, 2213-17-4)

Conditions	Yield
With tellurium; sodium tetrahydroborate In carbon disulfide; ethanol at 40℃; for 0.5h;	5%
Multi-step reaction with 3 steps 1: NaBH4 2: CF3SO3H / CH2Cl2 / -15 °C 3: 18 percent / H2O / acetone View Scheme
With sodium tetrahydroborate

canthaxanthin (514-78-3) → 11,15'-dihydrooxepino-β,β-carotene-4,4'-dione

Conditions	Yield
With 18-crown-6 ether; sodium 3-chlorobenzoate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at -20℃; for 30h;	2%

canthaxanthin (514-78-3) → 13,14-trans-canthaxanthin-13,14-ozonide + 13,14-cis-canthaxanthin-13,14-ozonide

Conditions	Yield
With 18-crown-6 ether; tert-butyl methyl ether; sodium 3-chlorobenzoate; 3-chloro-benzenecarboperoxoic acid In dichloromethane at 20℃; for 30h;	A 0.2% B 1%

canthaxanthin (514-78-3) → isozeaxanthin (29065-03-0, 68538-97-6, 84142-78-9, 84518-15-0, 106037-10-9, 125472-26-6, 21940-25-0)

Conditions	Yield
With lithium aluminium tetrahydride
With sodium tetrahydroborate In ethanol
With lithium aluminium tetrahydride In diethyl ether

canthaxanthin (514-78-3) → 6,5'-retro-5,6-dihydro-β,β-carotene-4,4'-dione (13186-17-9, 81369-49-5)

Conditions	Yield
With acetic acid; zinc In pyridine

canthaxanthin (514-78-3) → C40H52O2(2+) (113301-77-2) + C40H52O2(1+) (113349-54-5)

Conditions	Yield
Equilibrium constant; Rate constant; electrolysis;

canthaxanthin (514-78-3) → all-trans canthaxanthin radical cation + Canthaxanthin dication

Conditions	Yield
In dichloromethane electrooxidation, comproportionation equilibrium constants, deprotonation equilibrium constant;

canthaxanthin (514-78-3) → Phoeniconon (50299-51-9)

Conditions	Yield
With potassium tert-butylate; oxygen

canthaxanthin (514-78-3) → astacene (34026-74-9, 58769-83-8)

Conditions	Yield
With potassium tert-butylate; oxygen

canthaxanthin (514-78-3) → all-trans canthaxanthin radical cation

Conditions	Yield
With TX-100; trichloromethyl peroxyl In water Rate constant; Irradiation;

canthaxanthin (514-78-3) → neocanthaxanthin-C (32603-26-2) + 9-cis canthaxanthin (101915-55-3) + 13-cis canthaxanthin (514-78-3, 28999-90-8, 32603-26-2, 101915-53-1, 101915-54-2, 101915-55-3, 111058-45-8, 113349-54-5, 117857-54-2, 117857-55-3, 117857-56-4, 135969-90-3, 101915-56-4) + C40H52O2

Conditions	Yield
With tert-butylammonium hexafluorophosphate(V) In dichloromethane at 4℃; for 0.0833333h; Product distribution; Mechanism; electrolysis;
With iron(III) chloride In dichloromethane Product distribution; Mechanism;

canthaxanthin (514-78-3) → 9-cis canthaxanthin (101915-55-3) + 13-cis canthaxanthin (514-78-3, 28999-90-8, 32603-26-2, 101915-53-1, 101915-54-2, 101915-55-3, 111058-45-8, 113349-54-5, 117857-54-2, 117857-55-3, 117857-56-4, 135969-90-3, 101915-56-4)

Conditions	Yield
With zinc(II) oxide In dichloromethane for 0.25h; Product distribution; Irradiation; also CdS and without semiconductors;

canthaxanthin (514-78-3) → 11,15'-dihydrooxepino-β,β-carotene-4,4'-dione + 15'-formyl-15-nor-β,β-carotene-4,4'-dione + 12-formyl-11-nor-β,β-carotene-4,4'-dione + (13RS,15SR)-15',13-epoxy-vinyleno-13,14'-dihydro-14,15-dinor-β,β-carotene-4,4'-dione

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In benzene at 37℃; for 3h; Yield given; Further byproducts given. Yields of byproduct given;

canthaxanthin (514-78-3) → 15'-formyl-15-nor-β,β-carotene-4,4'-dione + 13,15'-epoxyvinyleno-13,15'-dihydro-14,15-dinor-β,β-carotene-4,4'-dione + 12-formyl-11-nor-β,β-carotene-4,4'-dione + (13RS,15SR)-15',13-epoxy-vinyleno-13,14'-dihydro-14,15-dinor-β,β-carotene-4,4'-dione

Conditions	Yield
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In benzene at 37℃; for 3h; Yield given; Further byproducts given. Yields of byproduct given. Title compound not separated from byproducts;
With 2,2'-azobis-(2,4-dimethylvaleronitrile) In benzene at 37℃; for 3h; Yield given; Further byproducts given. Yields of byproduct given;

Upstream product

• 128-08-5 N-Bromosuccinimide 
• 92-53-5 4-Phenylmorpholine 
• 64-17-5 ethanol 
• 67-66-3 chloroform 
• 7235-40-7 beta-carotene 
• 105819-60-1 5,6;5',6'-diseco-β,β-carotene-4,6,4',6'-tetraone 
• 106356-06-3 4'-hydroxy-β,β-caroten-4-one 
• 58540-69-5 4,4'-diacetoxy-β,β-carotene 
• 29065-03-0 isozeaxanthin 
• 5056-17-7 (2E,4E,6E)-2,7-dimethyl-2,4,6-octatrienedial 
• 71-43-2 benzene 
• 108-90-7 chlorobenzene 
• 190059-33-7 (E)-4-(1,3,3-Trimethyl-7-oxa-bicyclo[4.1.0]hept-2-yl)-but-3-en-2-one 
• 161023-01-4 β-carotene 

Downstream Products

• 106356-06-3 4'-hydroxy-β,β-caroten-4-one 
• 32603-26-2 neocanthaxanthin-C 
• 101915-55-3 9-cis canthaxanthin 
• 514-78-3 13-cis canthaxanthin 

Relevant articles and documents

Cantharidin preparation method

The invention belongs to the field of compound synthesis, and relates to a cantharidin preparation method, which comprises: carrying out an oxidation reaction on beta carotene in a solvent in the presence of an oxidizing agent, a catalyst and a strong acid salt of divalent manganese ions, performing standing for layering after the oxidation reaction is finished, washing and purifying the oil layer, and concentrating to remove the solvent, and then adding an isomerization solvent to carry out isomerization reaction, and filtering and drying after the isomerization reaction is finished to obtainthe all-trans cantharidin. The cantharidin prepared by adopting the method provided by the invention has the advantages of good oxidation effect, lower oxidant dosage and higher cantharidin yield (upto 86% or above), and the obtained cantharidin is a purple red acicular crystal with the content of more than 90%. Then, a water layer is treated by adopting the method provided by the invention andthen is recycled, so that the consumption of an oxidant can be reduced, the cost is reduced, and meanwhile, the discharge of halogen-free acid salt wastewater is realized.

Process method for synthesizing canthaxanthin

The invention relates to a process method for synthesizing canthaxanthin. The process method comprises the following steps: 1, oxidizing a compound (2) to obtain a compound (3); and 2, carrying out acondensation reaction on the compound (3) and decadialdehyde to obtain the final product canthaxanthin (1). The invention provides another process route for synthesizing canthaxanthin. The route is simple, only two steps are needed, the canthaxanthin is gradually separated out from a liquid reaction system in the reaction process, the purity is very high, further purification measures are not needed, the yield is not lower than that of an existing canthaxanthin preparation process, the purity is higher than that of the existing process, the cost is lower, and industrial popularization is easy.

Method for preparing canthaxanthin by oxidizing beta-carotene

The invention provides a method for preparing canthaxanthin by oxidizing beta-carotene. The method comprises the following steps of: dissolving beta-carotene in a solvent, and carrying out oxidation reaction in the presence of a catalyst and an oxidant to prepare canthaxanthin; wherein the catalyst is a metal calcium salt compound. The cheap metal calcium salt compound is used as the catalyst, anda peroxide is used as the oxidant to catalyze the oxidation reaction, so that the method has the advantages of mild process route conditions, environment friendliness, simple and convenient operationand easy industrial production.