514830-23-0

Basic information

• Product Name: Acetic acid, 2-[[3-(2-chlorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]hydrazide
• CAS NO: 514830-23-0
• Molecular Formula: C17H15ClN4O2
• Molecular Weight: 342.785
• Mol File: 514830-23-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Acetic acid, 2-[[3-(2-chlorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, 2-[[3-(2-chlorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]hydrazide(514830-23-0)
• EPA Substance Registry System: Acetic acid, 2-[[3-(2-chlorophenyl)-3,4-dihydro-4-oxo-2-quinazolinyl]methyl]hydrazide(514830-23-0)

Safety Data

• Hazardous Substances Data: 514830-23-0(Hazardous Substances Data)

Upstream product

• 61554-50-5 2-Bromomethyl-3-(2-chloro-phenyl)-3H-quinazolin-4-one 
• 340-57-8 mecloqualone 
• 75-36-5 acetyl chloride 
• 514830-19-4 3-(2-chloro-phenyl)-2-hydrazinomethyl-3H-quinazolin-4-one 

Downstream Products

• 514830-29-6 3-(4-dimethylamino-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-27-4 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-30-9 3-(4-methoxy-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-28-5 3-phenyl-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones

Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2′-yl)-6-monosubstitutedquinazolin-4 (3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydrazinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds of this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchalconylaminoazetidinon- 2′-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti-inflammatory activity and lower ulccrogenic liability than phenylbutazone and its toxicity is also quite low.