61554-50-5

Basic information

• Product Name: 2-(bromomethyl)-3-(2-chlorophenyl)-4(3H)-quinazolinone
• Synonyms: 2-(bromomethyl)-3-(2-chlorophenyl)-4(3H)-quinazolinone
• CAS NO: 61554-50-5
• Molecular Formula: C₁₅H₁₀BrClN₂O
• Molecular Weight: 349.6097
• Mol File: 61554-50-5.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(bromomethyl)-3-(2-chlorophenyl)-4(3H)-quinazolinone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(bromomethyl)-3-(2-chlorophenyl)-4(3H)-quinazolinone(61554-50-5)
• EPA Substance Registry System: 2-(bromomethyl)-3-(2-chlorophenyl)-4(3H)-quinazolinone(61554-50-5)

Safety Data

• Hazardous Substances Data: 61554-50-5(Hazardous Substances Data)

Upstream product

• 340-57-8 mecloqualone 

Downstream Products

• 514830-27-4 3-(4-hydroxy-3-methoxy-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-29-6 3-(4-dimethylamino-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-30-9 3-(4-methoxy-phenyl)-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-28-5 3-phenyl-acrylic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-23-0 acetic acid N'-[3-(2-chloro-phenyl)-4-oxo-3,4-dihydro-quinazolin-2-ylmethyl]-hydrazide 
• 514830-19-4 3-(2-chloro-phenyl)-2-hydrazinomethyl-3H-quinazolin-4-one 

Relevant articles and documents

Synthesis and anti-inflammatory activity of some new 2,3-disubstituted-6-monosubstituted-quinazolin-4(3H)-ones

Some new quinazolinone derivatives, 3-(substituted phenyl)-2-(substituted phenylchalconylaminoazetidinon-2′-yl)-6-monosubstitutedquinazolin-4 (3H)-ones have been synthesized by the reaction of 3-(substituted phenyl)-2-(substituted phenylchalconylhydrazinomethyl)-6-monosubstituted-quinazolin-4(3H)-ones with acetyl chloride in the presence of triethylamine. All the compounds of this series have been evaluated for their anti-inflammatory activity against carrageenan induced oedema in albino rats. The activity of the most active member of this series i.e. 3-(o-methoxyphenyl)-2-(p-dimethylaminophenylchalconylaminoazetidinon- 2′-yl) quinazolin-4(3H)-one has been studied in detial and is compared with phenylbutazone. Interestingly this compound exhibits better anti-inflammatory activity and lower ulccrogenic liability than phenylbutazone and its toxicity is also quite low.