51513-97-4

Basic information

• Product Name: Carbamic acid, (3-chloro-3-oxopropyl)-, phenylmethyl ester
• CAS NO: 51513-97-4
• Molecular Formula: C11H12ClNO3
• Molecular Weight: 241.674
• Mol File: 51513-97-4.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (3-chloro-3-oxopropyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (3-chloro-3-oxopropyl)-, phenylmethyl ester(51513-97-4)
• EPA Substance Registry System: Carbamic acid, (3-chloro-3-oxopropyl)-, phenylmethyl ester(51513-97-4)

Safety Data

• Hazardous Substances Data: 51513-97-4(Hazardous Substances Data)

Upstream product

• 501-53-1 benzyl chloroformate 
• 2304-94-1 3-(benzyloxycarbonylamino)propanoic acid 

Downstream Products

• 1374639-96-9 benzyl [(Z)-3-(1H-1,2,3-benzotriazol-1-yl)-3-(pyridin-2-ylimino)propyl]carbamate 
• 1374639-93-6 benzyl 3-(piperidin-1-yl)-3-(pyridin-2-ylimino)propylcarbamate 
• 71874-10-7 benzyl [3-oxo-3-(pyridin-2-ylamino)propyl]carbamate 
• 960073-95-4 C₃₁H₃₇N₃O₆ 
• 620961-47-9 C₂₅H₂₉N₃O₇ 
• 21612-28-2 N^α-(N-benzyloxycarbonyl-β-alanyl)-histidine 
• 21855-66-3 benzyl N-[2-(hydrazinecarbonyl)ethyl]carbamate 
• 364782-90-1 (R,R)-N',N'-bis(1'-phenylethyl)-N-benzyl-N-carbobenzyloxypropionamide 
• 948317-73-5 [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid 
• 875932-89-1 methyl N-(Cbz-β-alanyl)carbamate 

Relevant articles and documents

FERROPORTIN INHIBITORS AND METHODS OF USE

The subject matter described herein is directed to Ferroportin inhibitor compounds of Formula I and pharmaceutical salts thereof, methods of preparing the compounds, pharmaceutical compositions comprising the compounds and methods of administering the compounds for prophylaxis and/or treatment of diseases caused by a lack of hepcidin or iron metabolism disorders, particularly iron overload states, such as thalassemia, sickle cell disease and hemochromatosis.

Formamide catalyzed activation of carboxylic acids-versatile and cost-efficient amidation and esterification

A novel, broadly applicable method for amide C-N and ester C-O bond formation is presented based on formylpyrrolidine (FPyr) as a Lewis base catalyst. Herein, trichlorotriazine (TCT), which is the most cost-efficient reagent for OH-group activation, was employed in amounts of ≤40 mol% with respect to the starting material (100 mol%). The new approach is distinguished by excellent cost-efficiency, waste-balance (E-factor down to 3) and scalability (up to >80 g). Moreover, high levels of functional group compatibility, which includes acid-labile acetals and silyl ethers, are demonstrated and even peptide C-N bonds can be formed. In comparison to reported amidation procedures using TCT, yields are considerably improved (for instance from 26 to 91%) and esterification is facilitated for the first time in synthetically useful yields. These significant enhancements are rationalized by activation by means of acid chlorides instead of less electrophilic acid anhydride intermediates.

IMMUNOMODULATOR COMPOUNDS

Compounds are provided that are useful as immunomodulators. The compounds have the following Formula (II): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, R2a, R2b, R2c, R3, R4, R5, R6a, R6b, m and n are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.