948317-73-5

Basic information

• Product Name: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid
• Synonyms: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid
• CAS NO: 948317-73-5
• Molecular Weight: 369.205
• Mol File: 948317-73-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid(948317-73-5)
• EPA Substance Registry System: [3-(benzyloxycarbonylamino)-1-hydroxy-1-phosphonopropyl]phosphonic acid(948317-73-5)

Safety Data

• Hazardous Substances Data: 948317-73-5(Hazardous Substances Data)

Upstream product

• 40391-99-9 pamidronate 
• 1885-14-9 phenyl chloroformate 
• 2304-94-1 3-(benzyloxycarbonylamino)propanoic acid 
• 51513-97-4 N-[(phenylmethoxy)carbonyl]-β-alanine chloride 

Downstream Products

• 40391-99-9 pamidronate 

Relevant articles and documents

Syntheses of phosphonic esters of alendronate, pamidronate and neridronate

Several synthetic pathways for obtaining phosphonic esters of the amino bisphosphonic acids (NBPs) pamidronate, alendronate and neridronate were investigated. The general guideline was to react N-protected amino acids activated as phthalimide esters or as acyl chlorides. Succinimide esters were found less reactive and quickly abandoned. γ-Lactam formation arises when starting from Boc- or Cbz-protected amino acids. The phthalimide N-protecting group allowed access to alkyl or aryl mono-, di- (symmetric or not) and triesters of these three NBPs in high yields. Wiley-VCH Verlag GmbH & Co. KGaA, 2007.