51716-62-2

Basic information

• Product Name: Spiro[1,3-dioxolane-2,2'(1'H)-pentalen]-5'(3'H)-one, tetrahydro-, (3'aR,6'aS)-rel-
• Synonyms: Spiro[1,3-dioxolane-2,2'(1'H)-pentalen]-5'(3'H)-one, tetrahydro-, (3'aR,6'aS)-rel-;cis-Bicyclo[3.3.0]octane-3,7-dione monoethylene ketal;(3a'R,6a'S)-tetrahydro-1'H-spiro[[1,3]dioxolane-2,2'-pentalen]-5'(3'H)-one
• CAS NO: 51716-62-2
• Molecular Formula: C₁₀H₁₄O₃
• Molecular Weight: 182.21636
• Mol File: 51716-62-2.mol
• Article Data: 15

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Spiro[1,3-dioxolane-2,2'(1'H)-pentalen]-5'(3'H)-one, tetrahydro-, (3'aR,6'aS)-rel-(CAS DataBase Reference)
• NIST Chemistry Reference: Spiro[1,3-dioxolane-2,2'(1'H)-pentalen]-5'(3'H)-one, tetrahydro-, (3'aR,6'aS)-rel-(51716-62-2)
• EPA Substance Registry System: Spiro[1,3-dioxolane-2,2'(1'H)-pentalen]-5'(3'H)-one, tetrahydro-, (3'aR,6'aS)-rel-(51716-62-2)

Safety Data

• Hazardous Substances Data: 51716-62-2(Hazardous Substances Data)

Upstream product

• 74513-16-9 bicyclo[3.3.0]octane-3,7-dione 
• 107-21-1 ethylene glycol 
• 496847-14-4 n-propanol water 
• 69552-45-0 3,3,7,7-diethylenedioxy-cis-bicyclo[3.3.0]octane 
• 144-55-8 sodium hydrogencarbonate 
• 69552-47-2 methyl (+/-)-3-oxo-7,7-(ethylenedioxy)bicyclo<3.3.0>octane-2-carboxylate 
• 51716-63-3 cis-bicyclo[3. 3. 0]octane-3,7-dione 
• 69552-45-0 C₁₂H₁₈O₄ 

Downstream Products

• 93199-11-2 C₂₉H₃₈O₆S 
• 952137-48-3 (3aR,6aS)-5-(4-fluoro-phenyl)-5-hydroxy-hexahydro-pentalen-2-one 
• 247940-38-1 (3aR,5s,6aS)-3-hydroxy-7,7-(ethylidene acetal)bicyclo[3.3.0]octane 
• 51716-64-4 (3aR,5r,6aS)-3-hydroxy-7,7-(ethylidene acetal)bicyclo[3.3.0]octane 
• 19915-11-8 (3aRS,6aSR)-hexahydro-2(1H)-pentalenone 

Relevant articles and documents

A synthetic approach to 5/5/6-polycyclic tetramate macrolactams of the discodermide type

A flexible synthetic route to the 16-membered tetramate-embedding macrocyclic scaffold present in various polycyclic tetramate macrolactams (PTMs) was developed which differs from the seminal synthesis of ikarugamycin by Boeckman Jr. in protecting groups and the order of connections. We also devised a short approach to various stereoisomers of the 5/5/6-tricarbocyclic motif found in discodermide and other PTMs, starting from the Weiss’ diketone.

Bicyclic derivative-containing inhibitor, preparation method and applications thereof

The invention relates to a bicyclic derivative-containing inhibitor, a preparation method and applications thereof, particularly to a compound represented by a general formula (I), and a preparation method thereof, a pharmaceutical composition containing the compound, and applications of the compound as an Acetyl-CoA Carboxylase (ACC) inhibitor in treatment of diseases or symptoms caused by fattyacid metabolic disorder.

Octahydropentalene compound, and preparation method and medical application thereof

The invention relates to a novel octahydropentalene compound for regulating or inhibiting the activity of indoleamine 2,3-dioxygenase (IDO), and a preparation method and medicinal application of the octahydropentalene compound. Specifically, the invention relates to a compound as shown in a general formula (I) which is described in the specification and a pharmaceutically acceptable salt thereof,a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof, a method for treating and/or preventing related IDO-mediated diseases, especially tumors, by usingthe compound or the pharmaceutically acceptable salt thereof, and a preparation method for the compound or the pharmaceutically acceptable salt thereof. The invention also relates to the applicationof the compound or the pharmaceutically acceptable salt thereof or a pharmaceutical composition containing the compound or the pharmaceutically acceptable salt thereof in preparation of drugs for treating and/or preventing related IDO-mediated diseases, especially tumors. Each substituent of the general formula (I) is as defined in the specification.