69552-45-0Relevant articles and documents
A synthetic approach to 5/5/6-polycyclic tetramate macrolactams of the discodermide type
Bodenschatz, Kevin,St?ckl, Julia,Winterer, Markus,Schobert, Rainer
, (2022)
A flexible synthetic route to the 16-membered tetramate-embedding macrocyclic scaffold present in various polycyclic tetramate macrolactams (PTMs) was developed which differs from the seminal synthesis of ikarugamycin by Boeckman Jr. in protecting groups and the order of connections. We also devised a short approach to various stereoisomers of the 5/5/6-tricarbocyclic motif found in discodermide and other PTMs, starting from the Weiss’ diketone.