51782-87-7

Basic information

• Product Name: Cbz-L-proline-L-alanine methyl ester
• Synonyms: Cbz-L-proline-L-alanine methyl ester
• CAS NO: 51782-87-7
• Molecular Weight: 334.372
• Mol File: 51782-87-7.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: Cbz-L-proline-L-alanine methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Cbz-L-proline-L-alanine methyl ester(51782-87-7)
• EPA Substance Registry System: Cbz-L-proline-L-alanine methyl ester(51782-87-7)

Safety Data

• Hazardous Substances Data: 51782-87-7(Hazardous Substances Data)

Upstream product

• 2491-20-5 L-alanine methyl ester hydrochloride 
• 26607-48-7 1-benzyl hydrogen (S)-pyrrolidine-1,2-dicarboxylate, compound with dicyclohexylamine (1:1) 
• 133010-21-6 Z-L-Pro-F 
• 147-85-3 L-proline 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 766-09-6 1-ethyl-piperidine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 14030-00-3 (2S)-2-[({(2S)-1-[(benzyloxy)carbonyl]tetrahydro-1H-pyrrol-2-yl}carbonyl)amino]propanoic acid 
• 63095-75-0 Z-L-Pro-L-Ala-NH-Me 
• 134261-44-2 (1'S)-2--3-aza-4-methyl-5-methoxy-1-oxacyclopenta-2,4-diene 
• 90544-97-1 (S)-2-({(S)-1-[(S)-2-[(R)-2-[(R)-2-tert-Butoxycarbonylamino-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-methyl-benzylsulfanyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester 
• 90544-96-0 (S)-2-({(S)-1-[(S)-2-tert-Butoxycarbonylamino-3-(4-hydroxy-phenyl)-propionyl]-pyrrolidine-2-carbonyl}-amino)-propionic acid methyl ester 

Relevant articles and documents

Organocatalyzed Asymmetric Aldol Reaction of α-Keto Amides with A Tripeptide Catalyst

An organocatalyzed asymmetric aldol reaction of α-keto amides was developed. An N-terminal 4- trans -siloxyproline-based tripeptide with an l - tert -leucine unit adjacent to the 4- trans -siloxyproline residue was used to catalyze the reaction between various α-keto amides and acetone, to produce the corresponding aldol adducts with up to 99% yield and 91% ee.

Dynamic combinatorial libraries of hydrazone-linked pseudo-peptides: Dependence of diversity on building block structure and chirality

Expanding on our earlier building block architecture [(MeO) 2CH-Linker-Pro-X-NHNH2 where X = Phe, Cha], we have produced a series of new pseudo-dipeptides [(MeO)2CH-Linker-Pro-X- NHNH2 where X = Val, Leu, Ile, A

KINETICS OF THE ALKALINE HYDROLYSIS OF SEVERAL N-BENZYLOXYCARBONYLDIPEPTIDE METHYL AND ETHYL ESTERS

The reaction rates of the alkaline hydrolysis of synthesized N-protected dipeptide methyl and ethyl esters were studied systematically.From the kinetic data the energies of activation, the pre-exponential factors and the reference values at 40 deg C were calculated.The rate of hydrolysis shows to be strongly dependent on the C-terminal amino acid in the sequence Gly >> Ala/Met/Phe > Leu >> Val/Pro.Surprisingly the N-terminal amino acid also exerts an effect, but in a different sequence.N-Terminal Phe in particular shows a relative accelerating effect.Remarkable is the significantly faster ester hydrolysis of glycine containing dipeptide ethyl esters in ethanol/water compared to the corresponding methyl esters in methanol/water.