766-09-6 Usage
Description
1-Ethylpiperidine is a colorless liquid with a pepper-like odor, which is less dense than water. It has a flash point of 66°F and its vapors are heavier than air. 1-Ethylpiperidine may cause irritation to the skin and eyes.
Uses
Used in Pharmaceutical Industry:
1-Ethylpiperidine is used as a reactant for the synthesis of multiprotected kanosamine, which is an important intermediate in the development of pharmaceutical compounds.
Used in Chemical Synthesis:
1-Ethylpiperidine serves as a reagent for selective acylation in peptide synthesis, enabling the creation of specific peptide structures with desired properties.
Used in Organic Chemistry:
1-Ethylpiperidine is utilized in stereoselective aldol condensation reactions for the synthesis of β-lactam antibiotics, which are essential in the treatment of bacterial infections.
Used in Diastereoselective Synthesis:
1-Ethylpiperidine is employed in the diastereoselective synthesis of aldols, which are crucial in the development of various organic compounds with specific stereochemistry.
Used in Crossed Claisen Ester Condensation:
1-Ethylpiperidine is used as a reagent in crossed Claisen ester condensation reactions, which are important for the synthesis of complex organic molecules.
Used in Intermolecular Radical Additions:
1-Ethylpiperidine is used in the mediation of intermolecular radical additions to 2, 4, 6-trichlorophenyl vinyl sulfonate, contributing to the synthesis of various organic compounds.
Used in Room Temperature Phosphorescence:
1-Ethylpiperidine is employed in the room temperature phosphorescence of α-bromonaphthalene induced by cyclodextrin, with its application in the synthesis of 5-Bromopyrimidine, yielding up to 37%.
Used as a Solvent:
Due to its properties, 1-Ethylpiperidine is also used as a solvent in various chemical processes and for the production of other chemicals.
Synthesis Reference(s)
Organic Syntheses, Coll. Vol. 5, p. 575, 1973The Journal of Organic Chemistry, 28, p. 3259, 1963 DOI: 10.1021/jo01046a537
Reactivity Profile
1-Ethylpiperidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.
Health Hazard
May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.
Fire Hazard
Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.
Flammability and Explosibility
Highlyflammable
Safety Profile
Poison by intravenous
and subcutaneous routes. An eye irritant. A
very dangerous fire hazard when exposed to
heat or flame; can react vigorously with
oxidizing materials. When heated to
decomposition it emits toxic fumes of Nox.
Check Digit Verification of cas no
The CAS Registry Mumber 766-09-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 7,6 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 766-09:
(5*7)+(4*6)+(3*6)+(2*0)+(1*9)=86
86 % 10 = 6
So 766-09-6 is a valid CAS Registry Number.
InChI:InChI=1/C7H15N/c1-2-8-6-4-3-5-7-8/h2-7H2,1H3/p+1
766-09-6Relevant articles and documents
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Saegusa et al.
, p. 2991 (1967)
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PROCESS FOR CONVERTING AMIDE TO AMINE
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Page/Page column 23; 24, (2021/06/11)
Provided is a process for converting an amide into an amine comprising hydrogenation of the amide at a temperature not higher than 130°C and a hydrogen pressure not higher than 50 bar in the presence of a supported heterogeneous catalyst preparable by a method comprising depositing vanadium on a supported noble metal catalyst by impregnation.
Microwave-assisted nucleophilic degradation of organophosphorus pesticides in propylene carbonate
Millán, Daniela,Pavez, Paulina,Rojas, Mabel,Tapia, Ricardo A.
supporting information, p. 7868 - 7875 (2020/11/02)
Propylene carbonate is becoming a suitable green alternative to volatile organic solvents in the study of chemical reactions. In this study, an efficient method for nucleophilic degradation of five organophosphorus pesticides, fenitrothion, malathion, diazinon, parathion, and paraoxon, using propylene carbonate as a solvent is proposed. The effect of changing the nature of the nucleophile and the influence of microwave (MW) heating were investigated. A screening of temperatures (50 °C-120 °C) was performed under microwave heating. The pesticide degradation was followed by 31P NMR, and the extent of conversion (%) was calculated by the integration of phosphorus signals. Keeping in mind that recently it has been reported that some ionic liquids play a nucleophilic role, in this work we report for the first time the degradation of organophosphorus pesticides by using an amino acid-based ionic liquid such as Bmim[Ala] as a nucleophile and a bio-based solvent (propylene carbonate) as a reaction medium in combination with microwave heating. This journal is
