51833-69-3

Basic information

• Product Name: Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH
• Synonyms: SAR-ARG-VAL-TYR-ILE-HIS-PRO-PHE-OH
• CAS NO: 51833-69-3
• Molecular Formula: C49H71N13O10
• Molecular Weight: 1002.16914
• Mol File: 51833-69-3.mol
• Article Data: 3

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.38g/cm³
• Refractive Index: 1.65
• CAS DataBase Reference: Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH(CAS DataBase Reference)
• NIST Chemistry Reference: Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH(51833-69-3)
• EPA Substance Registry System: Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH(51833-69-3)

Safety Data

• Hazardous Substances Data: 51833-69-3(Hazardous Substances Data)

Usage

General Description

"Sar-Arg-Val-Tyr-Ile-His-Pro-Phe-OH" is a peptide consisting of nine amino acids. The peptide contains the amino acids sarkosyl (Sar), arginine (Arg), valine (Val), tyrosine (Tyr), isoleucine (Ile), histidine (His), proline (Pro), phenylalanine (Phe), and the carboxylic acid group (OH) at the C-terminus. This sequence of amino acids gives the peptide its unique properties and functions, and it may have potential applications in research, medicine, or other industries. Further study and analysis of this peptide may provide valuable insights and opportunities for its use in various fields.

InChI:InChI=1/C49H71N13O10/c1-6-29(4)41(46(69)58-36(24-32-25-53-27-55-32)47(70)62-21-11-15-38(62)44(67)59-37(48(71)72)23-30-12-8-7-9-13-30)61-43(66)35(22-31-16-18-33(63)19-17-31)57-45(68)40(28(2)3)60-42(65)34(56-39(64)26-52-5)14-10-20-54-49(50)51/h7-9,12-13,16-19,25,27-29,34-38,40-41,52,63H,6,10-11,14-15,20-24,26H2,1-5H3,(H,53,55)(H,56,64)(H,57,68)(H,58,69)(H,59,67)(H,60,65)(H,61,66)(H,71,72)(H4,50,51,54)/t29-,34?,35-,36-,37-,38-,40-,41-/m0/s1

Upstream product

• 68858-20-8 Fmoc-Val-OH 
• 71989-23-6 Fmoc-Ile-OH 
• 119831-72-0 Fmoc-Arg(Pbf)-OH 
• 77128-70-2 N-(9-fluorenylmethoxycarbonyl)sarcosine 
• 15761-39-4 1-(tert-butoxycarbonyl)-L-proline 
• 13139-16-7 N-(tert-butyloxycarbonyl)-L-isoleucine 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 
• 35899-43-5 Boc-His(Tos)-OH 

Relevant articles and documents

Angiotensin II analogues with sulphur-containing side-chains in position 5. A structure-activity relationship study

Four sets of angiotensin II (AngII) analogues with position 5 modifications, two agonist series with either Asp or Sar in position 1 and L- Phe in position 8, and two antagonist series with again Asp or Sar in position I and Leu in position 8 were synthesized. Modifications in positions 5 were introduced successively: Ile, Nle, Met, S-ethyl Cys, S-n-propyl-Cys, S-n-butyl Cys, S-t-butyl Cys and S-benzyl Cys in all four series. The study was undertaken in order to investigate the 5-position residue of AngII by replacing the hydrophobic side-chain by another containing an electrophilic moiety. The analogues were synthesised by solid phase synthesis using the Boc/Bzl or Fmoc/But strategy. All analogues were evaluated by their binding properties to the AT1 receptor on bovine adrenocortical membranes (bAT1). The results indicate that AngII analogues bind, irrespective of their agonistic or antagonistic nature or of their position 1 modification, in a similar manner and that position 5 modifications without β-branching behave in an additive manner towards their affinity.

Synthesis of peptides with the solid phase method. II. Octapeptide analogues of angiotensin II

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