52059-50-4Relevant articles and documents
Non-nucleoside inhibitors of human adenosine kinase: Synthesis, molecular modeling, and biological studies
Butini, Stefania,Gemma, Sandra,Brindisi, Margherita,Borrelli, Giuseppe,Lossani, Andrea,Ponte, Anna Maria,Torti, Andrea,Maga, Giovanni,Marinelli, Luciana,La Pietra, Valeria,Fiorini, Isabella,Lamponi, Stefania,Campiani, Giuseppe,Zisterer, Daniela M.,Nathwani, Seema-Maria,Sartini, Stefania,La Motta, Concettina,Da Settimo, Federico,Novellino, Ettore,Focher, Federico
experimental part, p. 1401 - 1420 (2011/04/24)
Adenosine kinase (AK) catalyzes the phosphorylation of adenosine (Ado) to AMP by means of a kinetic mechanism in which the two substrates Ado and ATP bind the enzyme in a binary and/or ternary complex, with distinct protein conformations. Most of the desc
Synthesis and biological activities of the marine bryozoan alkaloids convolutamines A, C and F, and lutamides A and C
Hashima, Hirofumi,Hayashi, Masahiko,Kamano, Yoshiaki,Sato, Nobuhiro
, p. 1757 - 1766 (2007/10/03)
Synthesis of convolutamines and lutamides, new 2,4,6-tribromo-3-methoxyphenethylamine alkaloids isolated from Floridian marine bryozoan Amathia convoluta, was accomplished by a sequence of reactions starting from 3-hydroxyphenethylamines. Cytotoxities of the synthetic lutamides, convolutamines and their de-O-methyl derivatives were examined using drug-sensitive and -resistant P388 as well as KB cell lines. The bioassay suggests that the 2,4,6-tribromo-3-methoxyphenethylamine is an indispensable unit for detection of the activities. Additionally, a reversal of drug resistance by those alkaloids is recognized. Copyright (C) 2000 Elsevier Science Ltd.
INTRAMOLECULAR RADICAL COUPLING OF A PHENOLIC ENOLATE: OXIDATIVE FRAGMENTATION OF THE SPIRODIKETONE INTERMEDIATE
Leboff, A.,Carbonelle, A.-C.,Alazard, J.-P.,Thal, C.,Kende, A. S.
, p. 4163 - 4164 (2007/10/02)
Ferricyanide oxidation of the dianion of the phenolic β-diketone 6b in basic conditions effects intramolecular radical coupling to form the spirocyclic diketone 7 which leads to the hydroxy tetralone 8 via an oxidative fragmentation process.