52386-52-4

Basic information

• Product Name: H-PHE-NHNH2
• Synonyms: H-PHE-NHNH2;L-PHENYLALANINE HYDRAZIDE;(S)-2-amino-3-phenylpropanehydrazide;L-Phenylalanine hydrazide≥ 98% (Assay by Titration)
• CAS NO: 52386-52-4
• Molecular Formula: C₉H₁₃N₃O
• Molecular Weight: 179.22
• Product Categories: Phenylalanine [Phe, F];Amino Acids and Derivatives;Amino Acids and Derivatives
• Mol File: 52386-52-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 410°Cat760mmHg
• Flash Point: 201.7°C
• Appearance: /
• Density: 1.175g/cm³
• Vapor Pressure: 6.25E-07mmHg at 25°C
• Refractive Index: 1.585
• Storage Temp.: Store at 0-5°C
• PKA: 12.86±0.50(Predicted)
• CAS DataBase Reference: H-PHE-NHNH2(CAS DataBase Reference)
• NIST Chemistry Reference: H-PHE-NHNH2(52386-52-4)
• EPA Substance Registry System: H-PHE-NHNH2(52386-52-4)

Safety Data

• Hazardous Substances Data: 52386-52-4(Hazardous Substances Data)

Usage

Chemical Properties

White powder

InChI:InChI=1/C9H13N3O/c10-8(9(13)12-11)6-7-4-2-1-3-5-7/h1-5,8H,6,10-11H2,(H,12,13)

Upstream product

• 7524-50-7 methyl (2S)-2-amino-3-phenylpropanoate hydrochloride 
• 7803-57-8 hydrazine hydrate 
• 63-91-2 L-phenylalanine 
• 1795-96-6 phenylalanine ethyl ester 
• 21820-50-8 DL-phenylalanine hydrazide 
• 2577-90-4 methyl (2S)-2-amino-3-phenylpropanoate 

Downstream Products

• 1356072-81-5 N'-[(2E/Z)-4-nitrobenzylidene]-(2S)-amino-3-phenylpropanehydrazide 
• 63-91-2 L-phenylalanine 
• 1448820-14-1 1-[(1-ethoxyethylene)amino]-2-methyl-4-benzylimidazol-5(4H)-one 
• 143668-40-0 5-benzyl-3-methyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one 
• 143668-41-1 5-benzyl-3-ethyl-1,4,5,6-tetrahydro-1,2,4-triazin-6(5H)-one 
• 1448820-15-2 1-[(1-ethoxypropylene)amino]-2-ethyl-4-benzylimidazol-5(4H)-one 
• 1448820-16-3 1-[(1-ethoxybenzylidene)amino]-2-phenyl-4-benzylimidazol-5(4H)-one 
• 1351400-23-1 2[(4-methoxybenzylidene)amino]-3-phenylpropinic acid (4-methoxybenzylidene)hydrazide 
• 350984-52-0 5-(S)-benzyl-3-[(S)-1-[N-(tert-butoxycarbonyl)amino]-2-phenethyl]-4,5-dihydro-1,2,4-triazin-6-(1H)-one 

Relevant articles and documents

Chiral arylideneaminoimidazolidin-4-ones: Green synthesis and isomerisation mechanism in solution

A green and eco-friendly synthetic approach of pure 2,5-disubstituted 3-arylideneaminoimidazolidin-4-ones is developed using water as the solvent. These new chiral arylideneaminoimidazolidin-4-one derivatives were obtained diastereoselectively in high ove

Synthesis of novel 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-ones and 1,2,4-triazin-6(5H)-ones from optically active α-aminocarboxylic acid hydrazides

New derivatives of 1-[(1-ethoxymethylene)amino]imidazol-5(4H)-one and 1,2,4-triazin-6(5H)-one were synthesized via reactions of optically active α-aminocarboxylic acid hydrazides and triethyl orthoesters in xylene. The factors influencing the formation of the unexpected five-membered products and attempts to elucidate the mechanism are discussed.

Synthesis and Antitubercular Activity of Novel Amino Acid Derivatives

In this work, 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. The compounds 8b, 8e, 8f, 9a-d, and 10c exhibited an important minimum inhibitory concentration activity between 12.5 and 50μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20μg/mL). In this work 17 new N-acylhydrazone derivatives of amino acids have been evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv. Eight compounds were non-cytotoxic and exhibited an important MIC activity between 12.5 and 50μg/mL, which can be compared with that of the tuberculostatic drug d-cycloserine (20μg/mL).