5256-61-1

Basic information

• Product Name: Lysergic Acid Hydrazide
• Synonyms: Lysergic Acid Hydrazide;(8β)-9,10-Didehydro-6-Methyl-ergoline-8-carboxylic Acid;D-9,10-Didehydro-6-Methyl-ergoline-8β-carboxylic Acid Hydrazide
• CAS NO: 5256-61-1
• Molecular Formula: C₁₆H₁₈N₄O
• Molecular Weight: 282.34032
• Product Categories: Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals
• Mol File: 5256-61-1.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Lysergic Acid Hydrazide(CAS DataBase Reference)
• NIST Chemistry Reference: Lysergic Acid Hydrazide(5256-61-1)
• EPA Substance Registry System: Lysergic Acid Hydrazide(5256-61-1)

Safety Data

• Hazardous Substances Data: 5256-61-1(Hazardous Substances Data)

Usage

Uses

Intermediate in the preparation of Lysergic Amide.

Upstream product

• 186581-53-3 diazomethane 
• 82-58-6 (+/-)-lysergic acid 
• 4579-64-0 lysergic acid methyl ester 
• 5256-60-0 (-)-isolysergic acid hydrazide 
• 5256-60-0 6-methyl-9,10-didehydro-ergoline-8-carboxylic acid hydrazide 

Downstream Products

• 478-94-4 (-)-isolysergic acid amide 
• 5256-60-0 (-)-lysergic acid hydrazide 
• 5256-60-0 (+/-)-isolysergic acid hydrazide 
• 478-94-4 (+/-)-isolysergic acid amide 
• 112746-02-8 (+/-)-isolysergic acid anilide 

Relevant articles and documents

Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor

Non-peptidic compounds containing the octahydro-indolo[4,3-fg]quinoline (ergoline) structural element have been optimized into derivatives with high affinity (pKd r sst1 > 9) and selectivity (>1000-fold for h sst1 over h sst2-h sst5) for the somatostatin sst1 receptor. In functional assays, these ergolines act as antagonists at human recombinant sst1 receptors. Pharmacokinetic studies in rodents reveal good oral bioavailability and brain penetration for some of these compounds.