5271-29-4

Basic information

• Product Name: 1,4-dimethyl-2-phenylpiperazine
• Synonyms: 1,4-dimethyl-2-phenylpiperazine
• CAS NO: 5271-29-4
• Molecular Weight: 190.288
• Mol File: 5271-29-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1,4-dimethyl-2-phenylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-dimethyl-2-phenylpiperazine(5271-29-4)
• EPA Substance Registry System: 1,4-dimethyl-2-phenylpiperazine(5271-29-4)

Safety Data

• Hazardous Substances Data: 5271-29-4(Hazardous Substances Data)

Upstream product

• 1074-12-0 phenylglyoxal hydrate 
• 110-70-3 N,N`-dimethylethylenediamine 
• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 5271-27-2 1-methyl-3-phenylpiperazine 
• 1072159-75-1 1-methyl-3-phenylpiperazine hydrochloride 

Relevant articles and documents

Biocatalytic Access to Piperazines from Diamines and Dicarbonyls

Given the widespread importance of piperazines as building blocks for the production of pharmaceuticals, an efficient and selective synthesis is highly desirable. Here we show the direct synthesis of piperazines from 1,2-dicarbonyl and 1,2-diamine substrates using the R-selective imine reductase from Myxococcus stipitatus as biocatalyst. Various N- and C-substituted piperazines with high activity and excellent enantioselectivity were obtained under mild reaction conditions reaching up to 8.1 g per liter.