5279-60-7

Basic information

• Product Name: N-(4-(tert-butyl)phenyl)-N-methylformamide
• Synonyms: N-(4-(tert-butyl)phenyl)-N-methylformamide
• CAS NO: 5279-60-7
• Molecular Weight: 191.273
• Mol File: 5279-60-7.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: N-(4-(tert-butyl)phenyl)-N-methylformamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-(tert-butyl)phenyl)-N-methylformamide(5279-60-7)
• EPA Substance Registry System: N-(4-(tert-butyl)phenyl)-N-methylformamide(5279-60-7)

Safety Data

• Hazardous Substances Data: 5279-60-7(Hazardous Substances Data)

Upstream product

• 64-18-6 formic acid 
• 5279-59-4 4-(1,1-dimethylethyl)-N-methylbenzenamine 
• 99-97-8 Dimethyl-p-toluidine 
• 123-39-7 N-Methylformamide 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 769-92-6 4-tert-Butylaniline 
• 63429-97-0 N-(4-(tert-butyl)phenyl)formamide 
• 2909-79-7 4-tert-butyl-N,N-dimethylaniline 
• 74-88-4 methyl iodide 

Relevant articles and documents

Ligand-Enabled Ni-Al Bimetallic Catalysis for Nonchelated Dual C-H Annulation of Arylformamides and Alkynes

A bifunctional secondary phosphine oxide (SPO) ligand-controlled method was developed for Ni-Al-catalyzed nonchelated dual C-H annulation of arylformamides with alkynes, providing a series of substituted amide-containing heterocycles in ≤97% yield. The SPO-bound bimetallic catalysis proved to be critical to the reaction efficiency.

Palladium-catalyzed intermolecular coupling of aryl halides and amides

The first general intermolecular C-N bond-forming reactions between aryl halides and amides were realized using a palladium catalyst with Xantphos as the ligand. Aryl triflates, carbamates, and sulfonamides are also viable substrates for the amidations, which proceed at 45-110 °C with 1-4 mol% of Pd catalyst in 66-99% yields and exhibit good functional group compatibility.