5293-52-7

Basic information

• Product Name: 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol
• Synonyms: 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol
• CAS NO: 5293-52-7
• Molecular Weight: 261.115
• Mol File: 5293-52-7.mol
• Article Data: 20

Chemical Properties

• CAS DataBase Reference: 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol(5293-52-7)
• EPA Substance Registry System: 6-bromo-3,4-dimethoxy-α-methylbenzyl alcohol(5293-52-7)

Safety Data

• Hazardous Substances Data: 5293-52-7(Hazardous Substances Data)

Upstream product

• 74-83-9 methyl bromide 
• 5392-10-9 2-bromo-4,5-dimethoxybenzaldehyde 
• 676-58-4 methylmagnesium chloride 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 54370-00-2 2-bromo-4,5-dimethoxybenzyl alcohol 
• 74-88-4 methyl iodide 
• 917-64-6 methyl magnesium iodide 
• 75-16-1 methylmagnesium bromide 

Downstream Products

• 1354364-37-6 2-(2-bromo-4,5-dimethoxyphenyl)butan-2-ol 
• 1401416-10-1 ethyl (2E)-3-{2-[1-(3-ethoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate 
• 1401416-26-9 tert-butyl (2E)-3-{2-[1-(3-tert-butoxy-3-oxopropoxy)ethyl]-4,5-dimethoxyphenyl}acrylate 
• 1394840-98-2 C₁₉H₁₉BrO₅ 
• 24126-93-0 6,7-dimethoxy-3-(3,4-dimethoxyphenyl)-4H-chromen-4-one 

Relevant articles and documents

α-Oxocarboxylic Acids as Three-Carbon Insertion Units for Palladium-Catalyzed Decarboxylative Cascade Synthesis of Diverse Fused Heteropolycycles

A novel palladium-catalyzed decarboxylative cascade cyclization for the assembly of diverse fused heteropolycycles by employing α-oxocarboxylic acids as three-carbon insertion units is reported. This protocol enables the synthesis of isoquinolinedione- and indolo[2,1-a]isoquinolinone-fused benzocycloheptanones in moderate to good yields by the use of different aryl iodides, including alkene-tethered 2-iodobenzamides and 2-(2-iodophenyl)-1H-indoles. Notably, the approach achieves simultaneous construction of both six- and seven-membered rings via sequential intramolecular carbopalladation, C-H activation, and decarboxylation.

Asymmetric Synthesis and Application of Chiral Spirosilabiindanes

Reported here is the development of a class of chiral spirosilabiindane scaffolds by Rh-catalyzed asymmetric double hydrosilation, for the first time. Enantiopure SPSiOL (spirosilabiindane diol), a new type of chiral building block for the preparation of various chiral ligands and catalysts, was readily prepared on greater than 10 gram scale using this protocol. The potential of this new spirosilabiindane scaffold in asymmetric catalysis was preliminarily demonstrated by development of the corresponding monodentate phosphoramidite ligands (SPSiPhos), which were used in both a Rh-catalyzed hydrogenation and a Pd-catalyzed intramolecular carboamination.

Phosphine- and water-promoted pentannulative aldol reaction

Herein, an efficient metal-free intramolecular aldol reaction for the synthesis of an unusual class of cyclopentanoids is described. The reaction of α-substituted dienones tethered with ketones in the presence of tributylphosphine and water provided aldols. The role of water was realised to be crucial for this transformation. Furthermore, isotopic labeling experiments provided vital information about the reaction mechanism.