52939-00-1

Basic information

• Product Name: 5-(4-NITROPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: 5-(4-NITROPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER;RARECHEM AL BF 0741;5-(4-nitrophenyl)-2-Furancarboxylic acid methyl ester;methyl 5-(4-nitrophenyl)furan-2-carboxylate
• CAS NO: 52939-00-1
• Molecular Formula: C₁₂H₉NO₅
• Molecular Weight: 247.2
• Mol File: 52939-00-1.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-NITROPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-NITROPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(52939-00-1)
• EPA Substance Registry System: 5-(4-NITROPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(52939-00-1)

Safety Data

• Hazardous Substances Data: 52939-00-1(Hazardous Substances Data)

Upstream product

• 611-13-2 2-furoic acid methyl ester 
• 586-78-7 para-nitrophenyl bromide 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 24067-17-2 4-nitrophenylboronic acid 

Downstream Products

• 28123-73-1 5-(4-nitrophenyl)-furan-2-carboxylic acid 
• 52939-06-7 5-(4-aminophenyl)furan-2-carboxylic acid methyl ester 

Relevant articles and documents

Synthesis and SAR of 5-aryl-furan-2-carboxamide derivatives as potent urotensin-II receptor antagonists

The synthesis and biological evaluation as potential urotensin-II receptor antagonists of a series of 5-arylfuran-2-carboxamide derivatives 1, bearing a 4-(3-chloro-4-(piperidin-4-yloxy)benzyl)piperazin-1-yl group, are described. The results of a systemat

(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1

A series of (5-arylfuran-2-ylcarbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2,5-disubstituted compounds appeared to have better activities than the other analogues, and the 2-methoxy-5- chlorophenyl compound 85 was found as a potent inhibitor of NHE-1 (IC 50 = 0.081 μM). Furthermore, 85 showed a marked reduction of infarct size in the rat myocardial infarction model in vivo and significant improvement of cardiac contractile function in the isolated rat heart ischemia model in vitro.