52939-06-7

Basic information

• Product Name: 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER
• Synonyms: SALOR-INT L300586-1EA;METHYL 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLATE;5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER;METHYL 5-(4-AMINOPHENYL)FURAN-2-CARBOXY&;Methyl 5-(4-aminophenyl)furan-2-carboxylate 97%
• CAS NO: 52939-06-7
• Molecular Formula: C₁₂H₁₁NO₃
• Molecular Weight: 217.22
• Mol File: 52939-06-7.mol
• Article Data: 2

Chemical Properties

• Melting Point: 122-126 °C(lit.)
• Boiling Point: 384.8°Cat760mmHg
• Flash Point: 186.5°C
• Appearance: /
• Density: 1.222g/cm³
• Vapor Pressure: 3.98E-06mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(52939-06-7)
• EPA Substance Registry System: 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER(52939-06-7)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Safety Statements: 26
• WGK Germany: 3
• Hazardous Substances Data: 52939-06-7(Hazardous Substances Data)

Usage

General Description

5-(4-aminophenyl)furan-2-carboxylic acid methyl ester is a chemical compound with a molecular formula C13H11NO3. It is an ester derivative of furan-2-carboxylic acid, containing a benzene ring substituted with an amino group at the 4-position. 5-(4-AMINOPHENYL)FURAN-2-CARBOXYLIC ACID METHYL ESTER is used in pharmaceutical research and as a building block in the synthesis of various drugs and bioactive molecules. It has been studied for its potential use in the treatment of certain diseases and conditions, and its structure and properties make it a valuable tool in drug discovery and development.

InChI:InChI=1/C12H11NO3/c1-15-12(14)11-7-6-10(16-11)8-2-4-9(13)5-3-8/h2-7H,13H2,1H3

Upstream product

• 24067-17-2 4-nitrophenylboronic acid 
• 2527-99-3 methyl 5-bromo-2-furoate 
• 52939-00-1 5-(4-nitrophenyl)furan-2-carboxylic acid methyl ester 

Downstream Products

• 864075-93-4 5-methyl 4-[(4-{[4-(4-butoxycarbonylamino)-1-methyl-1H-pyrrole-2-carbonyl]amino}-1-methyl-1H-pyrrole-2-carbonyl)amino]phenyl-2-furoate 
• 908580-99-4 methyl 5-{4-[(tert-butoxycarbonyl)amino]phenyl}-2-furoate 

Relevant articles and documents

(5-Arylfuran-2-ylcarbonyl)guanidines as cardioprotectives through the inhibition of Na+/H+ exchanger isoform-1

A series of (5-arylfuran-2-ylcarbonyl)guanidines was synthesized and evaluated for the NHE-1 inhibitory activity and cardiprotective efficacy against ischemia-reperfusion injury. Starting with (5-phenylfuran-2-ylcarbonyl) guanidine 47 with a moderate inhibitory effect on NHE-1, the compounds with various substituents at the phenyl ring were investigated with the aim to optimize the potency. In this study, the 2,5-disubstituted compounds appeared to have better activities than the other analogues, and the 2-methoxy-5- chlorophenyl compound 85 was found as a potent inhibitor of NHE-1 (IC 50 = 0.081 μM). Furthermore, 85 showed a marked reduction of infarct size in the rat myocardial infarction model in vivo and significant improvement of cardiac contractile function in the isolated rat heart ischemia model in vitro.