52997-82-7

Basic information

• Product Name: Pyrimidine, 4-(2-pyridinyl)-
• Synonyms: 4-(pyridin-2-yl)pyriMidine;Pyrimidine, 4-(2-pyridinyl)-
• CAS NO: 52997-82-7
• Molecular Formula: C₉H₇N₃
• Molecular Weight: 157.17
• Mol File: 52997-82-7.mol
• Article Data: 11

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Pyrimidine, 4-(2-pyridinyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrimidine, 4-(2-pyridinyl)-(52997-82-7)
• EPA Substance Registry System: Pyrimidine, 4-(2-pyridinyl)-(52997-82-7)

Safety Data

• Hazardous Substances Data: 52997-82-7(Hazardous Substances Data)

Usage

Description

Pyrimidine, 4-(2-pyridinyl)-, also known as 4-(2-pyridinyl)pyrimidine, is a heterocyclic aromatic organic compound with the molecular formula C9H7N3. It features a pyrimidine ring fused to a 2-pyridinyl group, making it a versatile building block in the synthesis of pharmaceuticals and agrochemicals. Pyrimidine, 4-(2-pyridinyl)exhibits a broad spectrum of biological activities and has been extensively studied for its potential applications in medicine and agriculture.

Uses

Used in Pharmaceutical Industry:
Pyrimidine, 4-(2-pyridinyl)is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved therapeutic properties and reduced side effects. It plays a crucial role in the creation of novel therapeutic agents for the treatment of various diseases and disorders.
Used in Agrochemical Industry:
In the agrochemical industry, Pyrimidine, 4-(2-pyridinyl)is utilized as a building block for the synthesis of new agrochemicals. Its incorporation into these compounds can lead to the development of more effective and environmentally friendly pesticides, herbicides, and other agricultural chemicals, ultimately contributing to increased crop yields and reduced environmental impact.
Used in Organic Synthesis:
Pyrimidine, 4-(2-pyridinyl)is also used as a precursor in the synthesis of various complex organic compounds. Its unique structure and reactivity make it a valuable component in the creation of advanced materials, specialty chemicals, and other organic compounds with diverse applications across various industries.

Upstream product

• 66521-54-8 3-(dimethylamino)-1-(pyridine-2-yl)prop-2-en-1-one 
• 463-52-5 formamidine 
• 1122-62-9 2-acetylpyridine 
• 17758-33-7 3-methyl-5-nitro-4(3H)-pyrimidinone 
• 289-95-2 PYRIMIDINE 
• 109-09-1 2-chloropyridine 
• 3473-63-0 formamidine acetic acid 
• 4774-33-8 tris(formylamino)methane 
• 66521-54-8 (2E)-3-(dimethylamino)-1-(2-pyridyl)prop-2-en-1-one 
• 17180-93-7 4-chloropyrimidine 
• 197958-29-5 pyridin-2-ylboronic acid 
• 77287-34-4 formamide 
• 17624-36-1 2-pyridyllithium 

Downstream Products

• 10198-90-0 6-phenyl-4-(2-pyridyl)pyrimidine 

Relevant articles and documents

The reaction of enaminones with carboxamidines: A convenient route for the synthesis of polyaza heterocycles

A simple and efficient synthetic method to polyaza heterocyclic structures containing 1,3-pyrimidine units has been developed. It is based on the reaction of the enaminones such as 5, 7 and 9 with the appropriate carboxamidines under basic conditions. By this procedure several new polyaza heterocycles have been prepared in good yields.

Mechanistic Studies on Ruthenium(II)-Catalyzed Base-Free Transfer Hydrogenation Triggered by Roll-Over Cyclometalation

The synthesis of 2-substituted pyridine–pyrimidine ligands and their complexation with arene ruthenium(II) chloride moieties is reported. Depending on the electronic and steric influences of the ligand, the catalysts undergo CH activation by roll-over cyclometalation. This process opens up the route to the catalytic transfer hydrogenation of ketones with isopropanol as the hydrogen source under base-free and mild conditions. Barriers related to the roll-over cyclometalation process can be determined experimentally by collision-induced dissociation ESI mass spectrometry. They are supported by DFT calculations and allow the classification of the ligands according to their electronic and steric properties, which is also in accordance with critical bond parameters derived from X-ray structure data. DFT calculations furthermore reveal that the formation of a ruthenium(II) hydrido species is plausible through β-hydride elimination from isopropanol.

Highly active and recyclable silica gel-supported palladium catalyst for mild cross-coupling reactions of unactivated heteroaryl chlorides

Silica gel-supported β-ketoiminatophosphane-Pd complex (Pd@SiO 2) was shown to be a highly active and long-lived catalyst for aqueous Suzuki, Stille and Sonogashira coupling reactions of heteroaryl chlorides. A wide range of heteroaryl chlorides could be efficiently coupled with different nucleophilic partners in the presence of only 0.5 mol% catalyst and under mild conditions. This is one of the most powerful heterogeneous catalysts for the couplings of diverse heteroaryl chlorides. Furthermore, the catalyst could be reused with almost consistent activity. The Royal Society of Chemistry 2010.