5311-71-7

Basic information

• Product Name: 3-(4-Methoxyphenyl)-5-methyl-1,2,4-oxadiazole
• Synonyms: 3-(4-Methoxyphenyl)-5-methyl-1,2,4-oxadiazole
• CAS NO: 5311-71-7
• Molecular Formula: C₁₀H₁₀N₂O₂
• Molecular Weight: 190.1986
• Mol File: 5311-71-7.mol
• Article Data: 16

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(4-Methoxyphenyl)-5-methyl-1,2,4-oxadiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-Methoxyphenyl)-5-methyl-1,2,4-oxadiazole(5311-71-7)
• EPA Substance Registry System: 3-(4-Methoxyphenyl)-5-methyl-1,2,4-oxadiazole(5311-71-7)

Safety Data

• Hazardous Substances Data: 5311-71-7(Hazardous Substances Data)

Upstream product

• 74903-79-0 N-hydroxy-4-methoxybenzenecarboximidoyl chloride 
• 75-05-8 acetonitrile 
• 127-19-5 N,N-dimethyl acetamide 
• 5373-87-5 4-methoxybenzamidoxime 
• 3717-21-3 p-methoxyl benzaldoxime 
• 123-11-5 4-methoxy-benzaldehyde 
• 64-19-7 acetic acid 
• 75-36-5 acetyl chloride 
• 141-78-6 ethyl acetate 
• 3717-22-4 (Z)-para-methoxybenzaldehyde oxime 
• 874-90-8 4-methoxybenzonitrile 
• 5373-87-5 (Z)-N'-hydroxy-4-methoxybenzenecarboximidamide 
• 79-20-9 acetic acid methyl ester 
• 949-02-0 C₁₀H₁₂N₂O₃ 

Downstream Products

• 49787-02-2 4-(5-methyl-1,2,4-oxadiazol-3-yl)phenol 

Relevant articles and documents

Imidazole hydrochloride promoted synthesis of 3,5-disubstituted-1,2,4-oxadiazoles

Imidazole hydrochloride as an additive promotes the reaction of amidoximes and DMA derivatives to generated 3,5-disubstituted-1,2,4-oxadiazoles in low to excellent yields without the use of coupling reagents, oxidants, strong acids or bases and other additives.

Efficient Synthesis of Functionalized Indene Derivatives via Rh(III)-Catalyzed Cascade Reaction between Oxadiazoles and Allylic Alcohols

A highly efficient rhodium(III)-catalyzed synthesis of novel functionalized indene derivatives has been achieved via C?H activation/intramolecular aldol condensation. This cascade reaction is an atom economical protocol which could be further applied to build more complex compounds. (Figure presented.).

Cobalt(III)-Catalyzed Oxadiazole-Directed C-H Activation for the Synthesis of 1-Aminoisoquinolines

Aromatic heterocycles have been identified as effective directing groups (DGs) in C-H functionalization but can be retained as undesired bulky substituents in the final products. Herein, we report a Co(III)-catalyzed 1-aminoisoquinoline synthesis strategy based on oxadiazole-directed aromatic C-H coupling with alkynes and a subsequent redox-neutral C-N cyclization reaction. This labile N-O bond-based protocol has allowed the toleration of a broad range of functional groups.