5333-62-0

Basic information

• Product Name: (Trityloxymethyl)benzene
• Synonyms: (Trityloxymethyl)benzene;Benzyl trityl ether;Benzyl(triphenylmethyl) ether;Benzyltrityl ether;Tritylbenzyl ether
• CAS NO: 5333-62-0
• Molecular Formula: C₂₆H₂₂O
• Molecular Weight: 350.4523
• Mol File: 5333-62-0.mol
• Article Data: 22

Chemical Properties

• Boiling Point: 463.8°Cat760mmHg
• Flash Point: 260.3°C
• Appearance: /
• Density: 1.107g/cm³
• Vapor Pressure: 2.44E-08mmHg at 25°C
• Refractive Index: 1.614
• CAS DataBase Reference: (Trityloxymethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: (Trityloxymethyl)benzene(5333-62-0)
• EPA Substance Registry System: (Trityloxymethyl)benzene(5333-62-0)

Safety Data

• Hazardous Substances Data: 5333-62-0(Hazardous Substances Data)

Usage

Description

(Trityloxymethyl)benzene is a compound that features a benzene ring with a trityloxymethyl group attached to it. This trityloxymethyl group serves as a protective group in organic synthesis, primarily to shield the reactivity of certain functional groups, such as alcohols and phenols. Its structure and reactivity contribute to its utility in various applications within the fields of pharmaceuticals, agrochemicals, and specialty chemicals, making it a significant tool in organic chemistry.

Uses

Used in Organic Synthesis:
(Trityloxymethyl)benzene is used as a protective group in organic synthesis to temporarily block the reactivity of functional groups, such as alcohols and phenols, for [application reason] facilitating complex molecular constructions without unwanted side reactions.
Used in Pharmaceutical Production:
(Trityloxymethyl)benzene is used as a building block in the production of pharmaceuticals for [application reason] its unique structure allows for the creation of a wide range of therapeutic molecules with specific properties and functions.
Used in Agrochemical Development:
(Trityloxymethyl)benzene is used as a component in the development of agrochemicals for [application reason] its reactivity and structural properties enable the synthesis of compounds with targeted effects on pests or crops.
Used in Specialty Chemicals:
(Trityloxymethyl)benzene is used as a key intermediate in the synthesis of specialty chemicals for [application reason] its versatility in organic chemistry allows for the production of tailored compounds for specific industrial applications.

InChI:InChI=1/C26H22O/c1-5-13-22(14-6-1)21-27-26(23-15-7-2-8-16-23,24-17-9-3-10-18-24)25-19-11-4-12-20-25/h1-20H,21H2

Upstream product

• 60-29-7 diethyl ether 
• 120-51-4 benzoic acid benzyl ester 
• 16002-63-4 phenylmagnesium iodide 
• 1140622-58-7 2'-deoxy-3',5'-bis-O-triphenylmethyluridine 
• 100-51-6 benzyl alcohol 
• 7791-71-1 5'-O-tritylthymidine 
• 23583-46-2 3'-O-acetyl-5'-O-triphenylmethylthymidine 
• 121356-00-1 3'-O-acetyl-2'-deoxy-5'-O-triphenylmethyluridine 
• 52417-07-9 3′,5′-di-O-trityl-thymidine 
• 14270-73-6 O^5'-trityl-2'-deoxy-uridine 
• 971-85-7 triphenylmethyl acetate 
• 92464-82-9 (2E)-3,7-dimethyl-1-triphenylmethoxy-2,6-octadiene 
• 5447-80-3 trityl phenoxide 
• 100-52-7 benzaldehyde 

Downstream Products

• 10276-85-4 benzyl caprylate 
• 39834-48-5 (4-methyl-benzyl)-trityl ether 
• 39834-47-4 (4-chloro-benzyl)-trityl ether 
• 39834-49-6 (((4-nitrobenzyl)oxy)methanetriyl)tribenzene 
• 39834-50-9 Triphenylmethyl (R,S)-sec-phenethyl ether 
• 28567-36-4 1-[phenyl(trityloxy)methyl]benzene 
• 20705-40-2 (cyclohexyloxy)triphenylmethane 
• 7500-77-8 (phenethyloxy)triphenylmethane 
• 13594-77-9 propyl triphenylmethyl ether 
• 76-84-6 triphenylmethyl alcohol 
• 100-51-6 benzyl alcohol 
• 76-83-5 trityl chloride 
• 92464-82-9 (2E)-3,7-dimethyl-1-triphenylmethoxy-2,6-octadiene 
• 5447-80-3 trityl phenoxide 

Relevant articles and documents

Temporal control in tritylation reactions through light-driven variation in chloride ion binding catalysis-a proof of concept

Tripodal triazole-linked azo(hetero)arene-based photoswitchable catalysts T1-5 have been designed, synthesized and optimized for the tritylation reaction of benzylamine (BzNH2). The tritylation reaction rates/yields achieved by light induced isomerization are compared between the native and photoswitched states of the catalyst T1. This concept of controlling the tritylation reaction rates with light has also been extended to additional substrates. The critical role of the triazole C-H?Cl- interactions has been confirmed by a combination of spectroscopic, calorimetric and computational studies. Also, the effect of variation in the binding affinities between the native and photoswitched states of the catalyst at room temperature in the temporal control of the catalysis has been demonstrated. This journal is

Stereoselective and Enantiospecific Mono- and Bis-C?H Azidation of Tr?ger Bases: Insight on Bridgehead Iminium Intermediates and Application to Anion-Binding Catalysis

In the context of Tr?ger base chemistry, regio- and stereoselective Csp3?H azidation reactions are reported. Azide functional groups are introduced at either one or the two benzylic positions selectively. Mild conditions and good yields are aff

Gold(I)-catalyzed synthesis of unsymmetrical ethers using alcohols as alkylating reagents

A microwave-irradiated alcohol-protecting strategy based on gold catalysis utilizing benzyl alcohol, tert-butyl alcohol and triphenylmethanol as alkylating reagents has been developed. This protecting strategy has wide functional group tolerance with satisfactory yields for the majority of the selected alcohols. The mechanism of this transformation was probed with oxygen-18 isotope labelled alcohols assisted by GC-MS techniques and chemical kinetic experiments. This strategy provides an efficient, straightforward and alternative approach to the preparation of benzyl, tert-butyl and trityl ethers in organic synthesis.