53330-45-3

Basic information

• Product Name: 1H-Indole, 1-benzoyl-2-phenyl-
• CAS NO: 53330-45-3
• Molecular Formula: C21H15NO
• Molecular Weight: 297.356
• Mol File: 53330-45-3.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 1H-Indole, 1-benzoyl-2-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Indole, 1-benzoyl-2-phenyl-(53330-45-3)
• EPA Substance Registry System: 1H-Indole, 1-benzoyl-2-phenyl-(53330-45-3)

Safety Data

• Hazardous Substances Data: 53330-45-3(Hazardous Substances Data)

Upstream product

• 21375-88-2 1-bromo-2-(phenylethenyl)benzene 
• 55-21-0 benzamide 
• 33348-34-4 4-amino-3-iodobenzonitrile 
• 1885-29-6 anthranilic acid nitrile 
• 1392323-07-7 N-(2-(1-phenylvinyl)phenyl)benzamide 
• 64097-92-3 2-(1-phenylvinyl)aniline 
• 2835-77-0 (2-aminophenyl)(phenyl)methanone 
• 95-14-7 1,2,3-Benzotriazole 
• 93-97-0 benzoic acid anhydride 
• 536-74-3 phenylacetylene 
• 4231-62-3 1-benzoyl-1H-benzotriazole 
• 35010-17-4 1-nitro-2-phenylethynyl-benzene 
• 615-43-0 2-iodophenylamine 
• 13141-38-3 2-phenylethynylaniline 

Downstream Products

• 948-65-2 2-phenyl-indole 

Relevant articles and documents

Preparation method of N-acyl indole compound

The invention discloses a preparation method of an N-acyl indole compound. The preparation method comprises the following steps: adding a palladium catalyst, potassium carbonate, a carbon monoxide substitute, 2-alkynylaniline and an aryl iodide into an or

Fluorine as a Traceless Directing Group for the Regiodivergent Synthesis of Indoles and Tryptophans

Despite ample evidence for the unique reactivity offered by hypervalent F-iodanes, mechanistic investigations fall far behind. In order to shed light on the unusual behavior of such F-reagents, we conducted computational and experimental studies on the chemodivergent transformation of styrenes. We identified the spirocyclic F-cyclopropane as the common intermediate for both the C,H-fluorination and C,H-amination pathways. The fate of this key compound is determined by the extent of cationic charge delocalization controlled by the N-substituents. Exploiting this phenomenon, a multitude of different transformations have become available, leading, i.e., to the regiodivergent synthesis of indoles and tryptophans.

Regioselective Synthesis of 2-Substituted Indoles from Benzotriazoles and Alkynes by Photoinitiated Denitrogenation

Herein, we describe a photoinitiated and regioselective synthesis of 2-substituted indoles under mild reaction conditions. This biologically privileged scaffold was accessed in good yields from N-aroylbenzotriazoles, a quencher class previously identified using our mechanism-based luminescence screening, and terminal alkynes in the presence of a photocatalyst and blue light irradiation. This straightforward protocol displays a broad substrate scope and functional group tolerance. Furthermore, the mildness and robustness of the reaction were assessed by the application of an additive-based robustness screen. The determination of the reaction quantum yield and Stern-Volmer studies support the proposed photoinitiated radical chain mechanism.