5343-52-2

Basic information

• Product Name: 2-ETHYL-2-METHYLPENTANOIC ACID
• Synonyms: 2-ethyl-2-methyl-valericaci;2-ETHYL-2-METHYLPENTANOIC ACID;2-ethyl-2-methylvaleric acid;2-Methyl-2-ethylpentanoic acid;Einecs 226-284-8;Nsc 466;Valeric acid, 2-ethyl-2-methyl-;Valproic Acid IMpurity K
• CAS NO: 5343-52-2
• Molecular Formula: C₈H₁₆O₂
• Molecular Weight: 144.21
• EINECS: 226-284-8
• Mol File: 5343-52-2.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 227.7°Cat760mmHg
• Flash Point: 102.5°C
• Appearance: /
• Density: 0.928g/cm³
• Refractive Index: 1.62
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 4.85±0.40(Predicted)
• CAS DataBase Reference: 2-ETHYL-2-METHYLPENTANOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ETHYL-2-METHYLPENTANOIC ACID(5343-52-2)
• EPA Substance Registry System: 2-ETHYL-2-METHYLPENTANOIC ACID(5343-52-2)

Safety Data

• Hazardous Substances Data: 5343-52-2(Hazardous Substances Data)

Usage

Description

2-Ethyl-2-methylpentanoic Acid, a derivative of 2,5-Dimethyl-2-ethylhexanoic Acid (D461540), is an organic compound with potential applications in various fields due to its unique chemical structure and properties.

Uses

Used in Environmental Chemical Studies:
2-Ethyl-2-methylpentanoic Acid is used as a chemical probe for evaluating the estrogenic potential of environmental chemicals. Its application is crucial in understanding the impact of these chemicals on the endocrine system and overall environmental health.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 2-Ethyl-2-methylpentanoic Acid may be utilized as a building block or intermediate in the synthesis of various drugs, targeting specific medical conditions. Its unique structure could contribute to the development of novel therapeutic agents.
Used in Chemical Synthesis:
2-Ethyl-2-methylpentanoic Acid can be employed as a versatile reagent in the synthesis of various organic compounds, including specialty chemicals, fragrances, and additives for different industries such as cosmetics, agriculture, and plastics.
Used in Analytical Chemistry:
As a reference compound, 2-Ethyl-2-methylpentanoic Acid can be used in analytical chemistry for the calibration of instruments, method development, and quality control processes, ensuring accurate and reliable results in chemical analysis.

InChI:InChI=1/C12H18N2O2S/c1-2-9-10(15)13-12(17)14(11(9)16)8-6-4-3-5-7-8/h8,16H,2-7H2,1H3,(H,13,15,17)

Upstream product

• 81923-96-8 ethyl α-methyl-α-ethylvalerate 
• 124-38-9 carbon dioxide 
• 64-18-6 formic acid 
• 2370-12-9 2,2-dimethylpentanol 
• 7664-93-9 sulfuric acid 
• 107-87-9 2-Pentanone 
• 5343-52-2 2-methyl-2-ethylpentanoic acid 
• 868-57-5 methyl 2-methylbutanoate 
• 589-34-4 3-methyl-hexane 
• 201230-82-2 carbon monoxide 
• 597-96-6 3-methyl-3-hexanol 
• 39255-32-8 manzanate 
• 7452-79-1 ethyl 2-methylbutyrate 
• 685892-30-2 3-bromo-3-methyl-heptan-4-one 

Downstream Products

• 5343-52-2 (+)-2-ethyl-2-methyl-valeric acid 
• 1541196-70-6 C₂₅H₃₀N₂O 

Relevant articles and documents

Auxiliary-Directed C(sp3)?H Arylation by Synergistic Photoredox and Palladium Catalysis

Herein we describe the auxiliary-directed arylation of unactivated C(sp3)?H bonds with aryldiazonium salts, which proceeds under synergistic photoredox and palladium catalysis. The site-selective arylation of aliphatic amides with α-quaternary centres is achieved with high selectivity for β-methyl C(sp3)?H bonds. This operationally simple method is compatible with carbocyclic amides, a range of aryldiazonium salts and proceeds at ambient conditions.

Copper-catalyzed site-selective intramolecular amidation of unactivated C(sp3)-H bonds

The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp3 C-H bond functionalization process. The reaction favors predominantly the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds. Moreover, a preference for activating sp3 C-H bonds of β-methyl groups, via a five-membered ring intermediate, over the aromatic sp2 C-H bonds was also observed in the cyclometalation step. Additionally, sp3 C-H bonds of unactivated secondary sp3 C-H bonds could be functionalized by favoring the ring carbon atoms over the linear carbon atoms. Getting ahead on tams: The intramolecular dehydrogenative amidation of aliphatic amides, directed by a bidentate ligand, was developed using a copper-catalyzed sp 3 C-H bond functionalization process to deliver β-lactams. The reaction favors the C-H bonds of β-methyl groups over the unactivated methylene C-H bonds, as well as aromatic C(sp2)-H bonds and unactivated secondary C(sp3)-H bonds of rings.

CARBONYLATION OF OLEFINS AND ALCOHOLS AT ATMOSPHERIC PRESSURE IN THE PRESENCE OF ACID CATALYSTS WITH ADDED Ag2O OR Cu2O

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