53483-66-2 Usage
General Description
1-Methyl-5-trifluoromethylbenzimidazole is a chemical compound with the molecular formula C9H7F3N2. It is a benzimidazole derivative with a methyl group and a trifluoromethyl group attached to the carbon atoms. 1-METHYL-5-TRIFLUOROMETHYLBENZIMIDAZOLE is primarily used as a building block for the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It has applications in the pharmaceutical industry for the development of new drugs, and in the agricultural industry for the production of pesticides and herbicides. The trifluoromethyl group in this compound can also impart desirable properties, such as increased lipophilicity and metabolic stability, in drug development and design. Overall, 1-methyl-5-trifluoromethylbenzimidazole is an important intermediate in organic synthesis with various industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 53483-66-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,4,8 and 3 respectively; the second part has 2 digits, 6 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 53483-66:
(7*5)+(6*3)+(5*4)+(4*8)+(3*3)+(2*6)+(1*6)=132
132 % 10 = 2
So 53483-66-2 is a valid CAS Registry Number.
InChI:InChI=1/C9H7F3N2/c1-14-5-13-7-4-6(9(10,11)12)2-3-8(7)14/h2-5H,1H3
53483-66-2Relevant articles and documents
Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes
Dong, Yaxi,Breit, Bernhard
supporting information, p. 6765 - 6769 (2021/09/11)
CuH-catalyzed intramolecular cyclization and intermolecular allylation of benzimidazoles with allenes have been described. The reaction proceeded smoothly with the catalytic system of Cu(OAc)2/Xantphos and catalytic amount of (MeO)2MeSiH. This protocol features mild reaction conditions and a good tolerance of substrates bearing electron-withdrawing, electron-donating, or electron-neutral groups. A new catalytic mechanism was proposed for this copper hydride catalytic system.
2-(4-ARYL-1H-IMIDAZOL-1-YL)ANILINE COMPOUNDS
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Paragraph 0069; 0103, (2015/11/27)
The present invention provides compounds that are useful as vaccine adjuvants and/or antitumor agents and methods for producing and using the same. In one particular aspect of the invention, compounds of the invention are of the formula (I) where R1, R2, R3 and Ar1 are those defined herein.
