53503-30-3

Basic information

• Product Name: (2,4-dimethylquinolin-3-yl)(phenyl)methanone
• Synonyms: (2,4-dimethylquinolin-3-yl)(phenyl)methanone
• CAS NO: 53503-30-3
• Molecular Weight: 247.296
• Mol File: 53503-30-3.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: (2,4-dimethylquinolin-3-yl)(phenyl)methanone(CAS DataBase Reference)
• NIST Chemistry Reference: (2,4-dimethylquinolin-3-yl)(phenyl)methanone(53503-30-3)
• EPA Substance Registry System: (2,4-dimethylquinolin-3-yl)(phenyl)methanone(53503-30-3)

Safety Data

• Hazardous Substances Data: 53503-30-3(Hazardous Substances Data)

Upstream product

• 5344-90-1 2-Aminobenzyl alcohol 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 529-23-7 o-aminobenzaldehyde 
• 495-40-9 propiophenone 
• 271-58-9 anthranil 
• 1621416-93-0 (Z)-1-phenyl-3-{2-[(E)-(2-phenylethenyl)]phenylamino}but-2-en-1-one 
• 93-91-4 1-phenylbutan-1,3-dione 
• 107522-67-8 3-benzoyl-2-methyl-quinoline-4-carboxylic acid 
• 110-89-4 piperidine 
• 64-17-5 ethanol 
• 552-89-6 2-nitro-benzaldehyde 
• 56969-57-4 C₁₇H₁₃NO₄ 
• 27652-35-3 (E)-2-styrylaniline 

Downstream Products

• 115533-96-5 (3-Cyano-1-phenyl-pyrrolo[3,4-b]quinolin-2-yl)-acetic acid 
• 91-63-4 2-methylquinoline 
• 65-85-0 benzoic acid 
• 53326-91-3 3-benzoyl-2-quinolinecarboxaldehyde 
• 101444-22-8 (2-methyl-[3]quinolyl)-phenyl ketone oxime 

Relevant articles and documents

Cascade Reaction of α, β-Unsaturated Ketones and 2-Aminoaryl Alcohols for the Synthesis of 3-Acylquinolines by a Copper Nanocatalyst

3-Acylquinolines possess widespread applications in functional chemicals. However, the convenient and selective synthesis of such important substructures has to date remained a challenge. Herein, we report a method to access 3-acylquinolines from α, β-unsaturated ketones and 2-aminoaryl alcohols in one pot with a copper nanocatalyst supported on nitrogen-silica-doped carbon (Cu/N?SiO2?C). Mechanistically, the construction of the product involves a cascade procedure including radical-type oxidation of 2-aminoaryl alcohols, aza-Michael addition and annulation. This developed protocol proceeds with merits of mild reaction conditions, good functional group tolerance, earth-abundant and reusable copper catalyst, easily available stocks and O2 as the sole oxidant, which provides an alternative way for the sustainable synthesis of quinoline derivatives. (Figure presented.).

α,β-Functionalization of saturated ketones with anthranils: Via Cu-catalyzed sequential dehydrogenation/aza-Michael addition/annulation cascade reactions in one-pot

An efficient method to access functionalized quinolines from the readily available saturated ketones and anthranils has been explored. This one-pot cascade reaction involves the in situ generation of α,β-unsaturated ketones by the copper catalysed dehydro

Manganese(III) acetate mediated oxidative radical cyclizations of N -(2-alkenylaryl)-substituted enamines

A method has been developed for the synthesis of highly functionalized quinolines from readily available N-(2-alkenylaryl)-substituted enamines via a 6-exo-trig radical cyclization of an imine radical. Several useful functional groups including morpholinocarbonyl, benzoyl, and cyano, are compatible with the reaction conditions. Under the Mn(II)/Co(II)/O2 redox system, these N-(2-alkenylaryl)enamines were also converted into the corresponding quinolines effectively. This strategy was further applied to related 1,4-naphthoquinone derivatives, and benzo[b]acridine-6,11-diones were formed in good yields.