53566-38-4

Basic information

• Product Name: TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE
• Synonyms: TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE;3-(TRI-N-BUTYLSTANNYL)BENZOTRIFLUORIDE;Tributyl[3-(trifluoromethyl)phenyl]stannane, tech;1-(Tributylstannyl)-3-(trifluoromethyl)benzene, [3-(Trifluoromethyl)phenyl]tributylstannane
• CAS NO: 53566-38-4
• Molecular Formula: C₁₉H₃₁F₃Sn
• Molecular Weight: 435.15
• Mol File: 53566-38-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 122-128°C 0,9mm
• Flash Point: 184.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.16E-05mmHg at 25°C
• CAS DataBase Reference: TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE(53566-38-4)
• EPA Substance Registry System: TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE(53566-38-4)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 22-36/37/39
• RIDADR: 3146
• Hazardous Substances Data: 53566-38-4(Hazardous Substances Data)

Usage

General Description

TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE is an organotin compound with the chemical formula C20H30F3Sn. It is a colorless to pale yellow liquid that is used as a reagent in organic synthesis, specifically in the preparation of various organotin derivatives. This chemical is a tributyltin (TBT) compound, which has been used as a component in antifouling paints for marine vessels. However, due to its toxic effects on marine life and its persistence in the environment, the use of TBT compounds has been restricted or banned in many countries. TRIBUTYL[3-(TRIFLUOROMETHYL)PHENYL]STANNANE should be handled and disposed of according to appropriate safety and environmental regulations to minimize its impact on the environment and human health.

InChI:InChI=1/C7H4F3.3C4H9.Sn/c8-7(9,10)6-4-2-1-3-5-6;3*1-3-4-2;/h1-2,4-5H;3*1,3-4H2,2H3;/rC19H31F3Sn/c1-4-7-13-23(14-8-5-2,15-9-6-3)18-12-10-11-17(16-18)19(20,21)22/h10-12,16H,4-9,13-15H2,1-3H3

Upstream product

• 401-78-5 3-bromo-1-trifluoromethylbenzene 
• 1461-22-9 tributyltin chloride 
• 98-17-9 3-Trifluoromethylphenol 
• 1075754-37-8 meta-trifluoromethylphenyl pivalate 
• 17955-46-3 trimethylsilyltributyltin 
• 813-19-4 bis(tri-n-butyltin) 

Downstream Products

• 1083330-10-2 dicarbonylcyclopentadienyl(m-trifluoromethylphenyl)iron 
• 5957-84-6 2-(3-trifluoromethylphenyl)pyridine 
• 1392840-02-6 1-benzyl-5-hydroxy-2-oxo-3-(3-trifluoromethyl-phenyl)-1,2-dihydro-[1,7]naphthyridine-6-carboxylic acid methyl ester 
• 1256278-83-7 1-(1-(4-chlorophenyl)-2,2-difluorovinyl)-3-(trifluoromethyl)benzene 
• 728-81-4 3-(trifluoromethyl)benzophenone 
• 92622-65-6 1-(3-(trifluoromethyl)benzoyl)-4-tert-butylcyclohex-1-ene 

Relevant articles and documents

Stannylation of Aryl Halides, Stille Cross-Coupling, and One-Pot, Two-Step Stannylation/Stille Cross-Coupling Reactions under Solvent-Free Conditions

Solvent-free protocols for palladium-catalyzed stannylation of aryl halides, Stille cross-coupling, and one-pot, two-step stannylation/Stille cross-coupling (SSC) are reported for the first time. (Het)aryl halides bearing acceptor, donor, as well as sterically demanding substituents are stannylated and/or coupled in high yields. The reactions are catalyzed by conventional palladium(II) acetate/PCy3 [Pd(OAc)2/PCy3] under air, using available base CsF, and without the use of high purity reagents. The developed synthetic procedures are versatile, robust, and easily scalable. The absence of solvent, and the elimination of isolation procedures of aryl stannanes makes the SSC protocol simple, step economical, and highly efficient for the synthesis of biaryls in a one-pot two-step procedure.

Pyrazolecarboxylic acid tricyclic derivatives, preparation and pharmaceutical compositions containing same

The subject of the invention is tricyclic derivatives of pyrazolecarboxylic acid of formula: in which R1 represents a C3-C15 carboxyl radical or an NR2R3 group. The invention also relates to the method for preparing the compounds of formula (I), pharmaceutical compositions containing them. The compounds of formula (I) are active on cannabinoid CB1 receptors.