53568-05-1

Basic information

• Product Name: 8-Hydroxy-2-tetralone
• Synonyms: 8-HYDROXY-2-TETRALONE;8-HYDROXY-3,4-DIHYDRONAPHTHALEN-2(1H)-ONE;8-Methoxyl-2-Tetralone;8-hydroxyl-2-tetralone;3,4-Dihydro-8-hydroxynaphthalen-2(1H)-one;4-dihydro-8-hydroxy-;8-Hydroxy-2-tetralone, 5-Hydroxy-3-oxo-1,2,3,4-tetrahydronaphthalene;2(1H)-Naphthalenone,3,4-dihydro-8-hydroxy-
• CAS NO: 53568-05-1
• Molecular Formula: C10H10O2
• Molecular Weight: 162.19
• Mol File: 53568-05-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 333.6°Cat760mmHg
• Flash Point: 141.8°C
• Appearance: /
• Density: 1.236g/cm³
• Vapor Pressure: 6.96E-05mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 8-Hydroxy-2-tetralone(CAS DataBase Reference)
• NIST Chemistry Reference: 8-Hydroxy-2-tetralone(53568-05-1)
• EPA Substance Registry System: 8-Hydroxy-2-tetralone(53568-05-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 53568-05-1(Hazardous Substances Data)

Usage

General Description

8-Hydroxy-2-tetralone is a chemical compound with the formula C10H10O2. It is a type of organic compound that belongs to the family of ketones. This chemical is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. It is also known for its antioxidant properties and has potential applications in the field of medicinal chemistry. Additionally, 8-Hydroxy-2-tetralone has been studied for its potential role in the treatment of neurodegenerative diseases, such as Alzheimer's and Parkinson's.Overall, this chemical shows promise for a wide range of applications in both the pharmaceutical and medical fields.

InChI:InChI=1/C10H10O2/c11-8-5-4-7-2-1-3-10(12)9(7)6-8/h1-3,12H,4-6H2

Upstream product

• 530-93-8 1,2,3,4-tetrahydronaphthalen-2-one 
• 5309-19-3 8-methoxy-2-tetralone 
• 6836-19-7 7-Methoxy-1-tetralone 
• 67247-13-6 7-methoxynaphth-1-ol 

Downstream Products

• 1374428-95-1 (S)-1,2,3,4-tetrahydronaphthalene-2,8-diyl bis(4-bromobenzoate) 

Relevant articles and documents

Tetrahydroxynaphthalene reductase: Catalytic properties of an enzyme involved in reductive asymmetric naphthol dearomatization

In reduced circumstances: Tetrahydroxynaphthalene reductase shows a broad substrate range including alternate phenolic compounds and cyclic ketones. Structural modeling reveals major enzyme-substrate interactions; C-terminal truncation of the enzyme causes an altered substrate preference, in accordance with stabilization of the substrate by the C-terminal carboxylate (see picture). This effect allows the identification of a homologous enzyme. Copyright

Chemokine receptor binding heterocyclic compounds

This invention relates to a novel class of heterocyclic compounds that bind chemokine receptors, inhibiting the binding of their natural ligands thereby. These compounds result in protective effects against infection by HIV through binding to chemokine receptors, including CXCR4 and CCR5, thus inhibiting the subsequent binding by these chemokines. The present invention provides a compound of Formula I wherein, W is a nitrogen atom and Y is absent or, W is a carbon atom and Y═H; R1to R7may be the same or different and are independently selected from hydrogen or straight, branched or cyclic C1-6alkyl; R8is a substituted heterocyclic group or a substituted aromatic group Ar is an aromatic or heteroaromatic ring each optionally substituted at single or multiple, non-linking positions with electron-donating or withdrawing groups; n and n′ are independently, 0-2; X is a group of the formula: Wherein, Ring A is an optionally substituted, saturated or unsaturated 5 or 6-membered ring, and P is an optionally substituted carbon atom, an optionally substituted nitrogen atom, sulfur or oxygen atom. Ring B is an optionally substituted 5 to 7-membered ring. Ring A and Ring B in the above formula can be connected to the group W from any position via the group V, wherein V is a chemical bond, a (CH2)n″group (where n″=0-2) or a C═O group. Z is, (1) a hydrogen atom, (2) an optionally substituted C1-6alkyl group, (3) a C0-6alkyl group substituted with an optionally substituted aromatic or heterocyclic group, (4) an optionally substituted C0-6alkylamino or C3-7cycloalkylamino group, (5) an optionally substituted carbonyl group or sulfonyl. These compounds further include any pharmaceutically acceptable acid addition salts and metal complexes thereof and any stereoisomeric forms and mixtures of stereoisomeric forms thereof.

HYDROXYLATION DU BENZALDEHYDE ET DE CETONES AROMATIQUES PAR LE PEROXYDE D'HYDROGENE EN MILIEU SUPERACIDE

Benzaldehyde and aromatic ketones are hydroxylated by hydrogen peroxide in SbF5-HF without formation of products arising from Baeyer-Villiger oxidation.