53578-43-1

Basic information

• Product Name: Benzene, 1-cyclopropyl-4-(1,1-dimethylethyl)-
• CAS NO: 53578-43-1
• Molecular Formula: C13H18
• Molecular Weight: 174.286
• Mol File: 53578-43-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Benzene, 1-cyclopropyl-4-(1,1-dimethylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-cyclopropyl-4-(1,1-dimethylethyl)-(53578-43-1)
• EPA Substance Registry System: Benzene, 1-cyclopropyl-4-(1,1-dimethylethyl)-(53578-43-1)

Safety Data

• Hazardous Substances Data: 53578-43-1(Hazardous Substances Data)

Upstream product

• 75-11-6 diiodomethane 
• 1746-23-2 4-tert-Butylstyrene 
• 1372474-95-7 sodium 3-(N-methyl-N-nitrososulfamoyl)benzoate 
• 3972-65-4 1-bromo-4-tert-butylbenzene 
• 411235-57-9 cyclopropylboronic acid 
• 253185-03-4 tert-butylbenzene 
• 1607-29-0 bis((1-methylcyclopropyl)formyl)peroxide 

Downstream Products

• 939-97-9 4-tert-Butylbenzaldehyde 
• 119200-35-0 5-(4-tert-Butylphenyl)-4,5-dihydroisoxazole 
• 86604-07-1 4-tert-butylcinnamaldehyde 
• 862188-37-2 1-(4-tert-butylphenyl)-1,3-propanediol 
• 53578-73-7 4-tert.-Butyl-2-bromphenylcyclopropan 
• 56786-74-4 1-(4-(tert-butyl)phenyl)propyl acetate 

Relevant articles and documents

The copper-catalyzed ring-opening reactions of cyclopropanes by N-fluorobenzenesulfonimide toward N-allylsulfonamides

In this paper, we reported a copper-catalyzed ring-opening reaction of arylcyclopropanes by N-fluorobenzenesulfonimide, leading to N-allylsulfonamides in moderate to good yields. This procedure tolerated bromo, fluoro, trifluoromethyl, phenyl and alkyl groups in the phenyl, proceeding with a sequential ring-opening of arylcyclopropanes, and copper-mediated β-H elimination of alkyl radical.

Lewis Base-Promoted Ring-Opening 1,3-Dioxygenation of Unactivated Cyclopropanes Using a Hypervalent Iodine Reagent

A facile and effective system has been developed for the regio- and chemoselective ring-opening/electrophilic functionalization of cyclopropanes through C?C bond activation by [bis(trifluoroacetoxy)iodo]benzene with the aid of the Lewis basic promoter p-toluenesulfonamide. The p-toluenesulfonamide-promoted system works well for a wide range of cyclopropanes, resulting in the formation of 1,3-diol products in good yields and regioselectivity.

Iron-catalyzed cyclopropanation in 6 M KOH with in situ generation of diazomethane

Diazomethane is a common and versatile reagent in organic synthesis whose broader use is generally impeded by its explosiveness and toxicity. Here we report that a simple iron porphyrin complex catalyzes the cyclopropanation of styrenes, enynes, and dienes under the demanding conditions [aqueous 6 molar potassium hydroxide (KOH) solution, open to air] necessary for the in situ generation of diazomethane from a water-soluble diazald derivative. A biphasic reaction medium arising from the immiscibility of the olefin substrates with water appears essential to the overall efficiency of the process. The work we describe highlights an approach to catalysis with untoward reactive intermediates, in which the conditions for their generation under operationally safe regimes dictate catalyst selection.