53688-18-9

Basic information

• Product Name: Ethanone, 2-chloro-1-(3-fluorophenyl)- (9CI)
• Synonyms: Ethanone, 2-chloro-1-(3-fluorophenyl)- (9CI);2-Chloro-1-(3-Fluorophenyl)Ethanone;2-Chloro-5'-fluoroacetophenone;3-Fluorophenacyl Chloride;M-Fluorophenacyl Chloride;α-Chloro-3'-fluoroacetophenone;2-Chloro-5'-Difluoroacetophenone;2-Chloro-1-(3-fluorophenyl)
• CAS NO: 53688-18-9
• Molecular Formula: C₈H₆ClFO
• Molecular Weight: 172.5840432
• Product Categories: ACETYLHALIDE;Aromatics;Intermediates
• Mol File: 53688-18-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 240.27 °C at 760 mmHg
• Flash Point: 99.112 °C
• Appearance: /
• Density: 1.264 g/cm³
• Storage Temp.: 2-8°C
• CAS DataBase Reference: Ethanone, 2-chloro-1-(3-fluorophenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2-chloro-1-(3-fluorophenyl)- (9CI)(53688-18-9)
• EPA Substance Registry System: Ethanone, 2-chloro-1-(3-fluorophenyl)- (9CI)(53688-18-9)

Safety Data

• Hazardous Substances Data: 53688-18-9(Hazardous Substances Data)

Usage

Description

Ethanone, 2-chloro-1-(3-fluorophenyl)(9CI) is an organic compound with a molecular structure that features a chloro group attached to the second carbon of the acetone backbone and a 3-fluorophenyl group attached to the first carbon. Ethanone, 2-chloro-1-(3-fluorophenyl)(9CI) is characterized by its unique chemical properties, which make it a valuable intermediate in the synthesis of various pharmaceutical compounds.

Uses

Used in Pharmaceutical Industry:
Ethanone, 2-chloro-1-(3-fluorophenyl)(9CI) is used as a synthetic intermediate for the development of neurologically active pharmaceutical compounds. Its unique molecular structure allows for the creation of new drugs that can potentially target and treat various neurological disorders and conditions.
Used in Chemical Synthesis:
In addition to its pharmaceutical applications, Ethanone, 2-chloro-1-(3-fluorophenyl)(9CI) can also be utilized as a synthetic intermediate in the chemical industry. Its versatile structure enables the synthesis of a wide range of compounds with diverse applications, including but not limited to, agrochemicals, dyes, and other specialty chemicals.

Upstream product

• 350-51-6 3-fluorostyrene 
• 53631-18-8 2-bromo-1-(3-fluorophenyl)ethanone 
• 455-36-7 1-(3-fluorophenyl)ethanone 

Downstream Products

• 1035097-22-3 1-chloro-2-(3-fluorophenyl)-3-(2-chlorophenyl)propan-2-ol 
• 125997-01-5 1-(3-fluorophenyl)-4-penten-1-one 
• 455-36-7 1-(3-fluorophenyl)ethanone 
• 1415240-38-8 C₁₇H₁₈FNO 
• 53688-13-4 6-chloro-2-(3-fluoro-phenyl)-3H-pyrido[2,3-b][1,4]thiazine 

Relevant articles and documents

The Mn-catalyzed paired electrochemical facile oxychlorination of styrenes: Via the oxygen reduction reaction

Reported herein is the electrochemical engendering of chlorine radicals by a manganese catalyst with a controllable pattern, and inexpensive MgCl2 as the chlorine source. In combination with the oxygen reduction reaction, chloroacetophenones were synthesized with abundant styrene as the feedstock in good to excellent yields.

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

Pd-catalyzed domino carbonylative-decarboxylative allylation: An easy and selective monoallylation of ketones

In the presence of an allyl alcohol, α-chloroacetophenones undergo an allyloxycarbonylation reaction followed by in situ decarboxylative allylation to selectively afford the corresponding monoallylated ketones via a Pd-catalyzed domino sequence. The scope of the reaction was extended to substituted α-chloroacetophenones as well as various allyl alcohols.