53786-45-1 Usage
Description
Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate is a chemical compound that is identified as an impurity in Domperidone (D531100), a novel peripheral dopamine receptor antagonist. ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate does not cross the blood-brain barrier and is known for its anti-emetic properties. It is derived from the chemical structure of Domperidone, which is a dopamine blocker and an antidopaminergic reagent.
Uses
Used in Pharmaceutical Industry:
Ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate is used as an impurity in the production of Domperidone (Motilium) for its application as a dopamine blocker and antidopaminergic reagent. ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate plays a role in the development and formulation of Domperidone, which is utilized for its anti-emetic effects and as a peripheral dopamine receptor antagonist that does not cross the blood-brain barrier.
Used in Research and Development:
In the field of pharmaceutical research and development, ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate may be used to study the effects and interactions of Domperidone with dopamine receptors. This can contribute to the understanding of the compound's mechanism of action and its potential applications in treating various conditions related to dopamine receptor activity.
Check Digit Verification of cas no
The CAS Registry Mumber 53786-45-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 5,3,7,8 and 6 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 53786-45:
(7*5)+(6*3)+(5*7)+(4*8)+(3*6)+(2*4)+(1*5)=151
151 % 10 = 1
So 53786-45-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H20ClN3O2/c1-2-20-14(19)18-7-5-11(6-8-18)17-13-4-3-10(15)9-12(13)16/h3-4,9,11,17H,2,5-8,16H2,1H3
53786-45-1Relevant articles and documents
Method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate
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Paragraph 0007; 0020; 0023; 0029; 0033; 0037, (2018/09/08)
The invention provides a method for synthesizing ethyl 4-[(2-amino-4-chloro)phenyl]-amino-N-piperidinecarboxylate. A reaction route of the method is as described in the specification. The invention has the following beneficial effects: 1, the novel synthetic method is designed in the invention for preparation of a domperidone intermediate with a structure as shown in a formula (DP-2) and is implemented, and the method uses easily available raw materials and is high in safety coefficient, simple in reaction and beneficial for realizing of large-scale industrial production; and 2, no special production equipment is need in the method, industrial scale-up production can be easily carried out, and production cost for the domperidone intermediate is greatly lowered, so production cost for domperidone is substantially reduced.
Synthesis and neuroleptic activity of a series of 1-[1-(benzo-1,4-dioxan-2-ylmethyl)-4-piperidinyl]benzimidazolone derivatives
Henning,Lattrell,Gerhards,Leven
, p. 814 - 820 (2007/10/02)
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