53786-46-2

Basic information

• Product Name: ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate
• Synonyms: ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate;ETHYL 4-(5-CHLORO-2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-2-YL)PIPERIDINE-1-CARBOXYLATE;4-[(5-Chloro-2,3-dihydro-2-oxo-1H-benzimidazol)-1-yl]-1-piperidinecarboxylic acid ethyl ester;Einecs 258-776-3;1-Piperidinecarboxylic acid, 4-(5-chloro-2,3-dihydro-2-oxo-1H-benziMidazol-1-yl)-, ethyl ester;ETHYL 4-(5-CHLORO-2,3-DIHYDRO-2-OXO-1H-BENZIMIDAZOL-1-YL)PIPERIDINE-1-CARBOXYLATE(WXG00906)
• CAS NO: 53786-46-2
• Molecular Formula: C₁₅H₁₈ClN₃O₃
• Molecular Weight: 323.77472
• EINECS: 258-776-3
• Mol File: 53786-46-2.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Density: 1.352g/cm³
• Refractive Index: 1.595
• CAS DataBase Reference: ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate(53786-46-2)
• EPA Substance Registry System: ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate(53786-46-2)

Safety Data

• Hazardous Substances Data: 53786-46-2(Hazardous Substances Data)

Usage

General Description

Ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate is a chemical compound with a complex structure and a long name. It consists of ethyl ester, piperidine, and benzimidazole moieties, and the presence of a chlorine atom and oxo group in the benzimidazole ring. ethyl 4-(5-chloro-2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)piperidine-1-carboxylate is used in the pharmaceutical industry for its potential biological activities and medicinal properties. It may have applications in the development of new drugs for the treatment of various diseases or conditions. The specific properties and potential uses of this compound may require further research and testing.

InChI:InChI=1/C15H18ClN3O3/c1-2-22-15(21)18-7-5-11(6-8-18)19-13-4-3-10(16)9-12(13)17-14(19)20/h3-4,9,11H,2,5-8H2,1H3,(H,17,20)

Upstream product

• 75-44-5 phosgene 
• 53786-45-1 ethyl 4-[(2-amino-4-chlorophenyl)amino]piperidine-1-carboxylate 
• 89-61-2 2,5-dichloronitrobenzene 
• 58859-46-4 ethyl 4-aminopiperidine-1-carboxylate 
• 53786-44-0 4-(4-chloro-2-nitro-anilino)-piperidine-1-carboxylic acid ethyl ester 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 53786-28-0 5-chloro-1-(piperidin-4-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one 
• 85076-06-8 axamozide 

Relevant articles and documents

Benzodiazepine calcitonin gene-related peptide (CGRP) receptor antagonists: Optimization of the 4-substituted piperidine

In our continuing effort to identify CGRP receptor antagonists for the acute treatment of migraine, we have undertaken a study to evaluate alternative 4-substituted piperidines to the lead dihydroquinazolinone 1. In this regard, we have identified the piperidinyl-azabenzimidazolone and phenylimidazolinone structures which, when incorporated into the benzodiazepine core, afford potent CGRP receptor antagonists (e.g., 18 and 29). These studies produced a potent analog (18) which overcomes the instability issues associated with the lead structure 1. A general pharmacophore for the 4-substituted piperidine component of these CGRP receptor antagonists is also presented.

Neuroleptic n-oxacyclyl-alkylpiperidine derivatives

Neuroleptically active compounds of the formula STR1 wherein R6 and R10 are --H or CH3 ; R7 and R8 are independently --H, --F, --Cl, or --CH3 ; and R9 is --F, --Cl, --CH3, or --OCH3.