53821-21-9Relevant articles and documents
Ni-Catalyzed Carboxylation of Unactivated Alkyl Chlorides with CO2
B?rjesson, Marino,Moragas, Toni,Martin, Ruben
supporting information, p. 7504 - 7507 (2016/07/06)
A catalytic carboxylation of unactivated primary, secondary, and tertiary alkyl chlorides with CO2 at atmospheric pressure is described. This protocol represents the first intermolecular cross-electrophile coupling of unactivated alkyl chlorides, thus leading to new knowledge in the cross-coupling arena.
Iron-catalyzed alkylations of aryl sulfamates and carbamates
Silberstein, Amanda L.,Ramgren, Stephen D.,Garg, Neil K.
supporting information; experimental part, p. 3796 - 3799 (2012/08/28)
The alkylation of aryl sulfamates and carbamates using iron catalysis is reported. The method constructs sp2-sp3 carbon-carbon bonds and provides synthetically useful yields across a range of substrates (>35 examples). The directing group ability of sulfamates and carbamates, accompanied by their low reactivity toward conventional cross-couplings, renders these substrates useful for the synthesis of polyfunctionalized arenes.
Preparation of polyfunctional zinc organometallics using an Fe- or Co-catalyzed Cl/Zn-exchange
Melzig, Laurin,Diene, Coura R.,Rohbogner, Christoph J.,Knochel, Paul
supporting information; experimental part, p. 3174 - 3177 (2011/08/06)
A new Fe- or Co-catalyzed Cl/Zn-exchange reaction allows the direct transformation of aryl, heteroaryl, and also alkyl chlorides into the corresponding zinc reagents. The method tolerates functional groups such as a nitrile or an ester. Remarkably, secondary and tertiary alkyl chlorides are suitable substrates for the Cl/Zn exchange.
