71126-73-3Relevant articles and documents
A selective and efficient demesylation using methylmagnesium bromide
Cossy,Ranaivosata,Bellosta,Wietzke
, p. 3109 - 3112 (1995)
The chemoselective regeneration of alcohols from mesylates was accomplished by using methylmagnesium bromide in THF.
Nematicidal activity of benzyloxyalkanols against pine wood nematode
Kim, Junheon,Lee, Su Jin,Park, Joon Oh,Yoon, Kyungjae Andrew
, p. 1 - 9 (2021/03/15)
Pine wilt disease (PWD) is caused by the pine wood nematode (PWN; Bursaphelenchus xylophilus) and causes severe environmental damage to global pine forest ecosystems. The current strategies used to control PWN are mainly chemical treatments. However, the continuous use of these reagents could result in the development of pesticide-resistant nematodes. Therefore, the present study was undertaken to find potential alternatives to the currently used PWN control agents abamectin and emamectin. Benzyloxyalkanols (BzOROH; R = C2–C9 ) were synthesized and the nematicidal activity of the synthetic compounds was investigated. Enzymatic inhibitory assays (acetylcholinesterase (AChE) and glutathione S-transferase (GST)) were performed with BzOC8OH and BzOC9OH to understand their mode of action. The benzyloxyalkanols showed higher nematicidal activity than did benzyl alcohol. Among the tested BzOROHs, BzC8OH and BzC9OH showed the strongest nematicidal activity. The LD50 values of BzC8OH and BzC9OH were 246.1 and 158.0 ppm, respectively. No enzyme inhibitory activity was observed for BzC8OH and BzC9OH. The results suggested that benzyloxyalcohols could be an alternative nematicidal agent.
Radiosynthesis of novel N-18F-labeled 18F-FHex-α-l-Glu and 18F-FHex-β-Glu
Wen, Fuhua,Liu, Shaoyu,Ma, Hui,Tang, Ganghua
, p. 222 - 230 (2020/04/02)
N-18F-labeled amino acids are important substitutes for new positron emission tomography (PET) imaging tracers complementing the deficiency of 18F-fluorodeoxyglucose (18F-FDG). In this work, two novel N-6-18F-alkyl amino acid imaging agents, 18F-FHex-α-l-Glu and 18F-FHex-β-Glu, were designed and synthesized as potential probes for PET imaging of tumors. 18F-FHex-α-l-Glu was synthesized using the precursor 6 from 18F-F? with the yield of 16 ± 4% (n = 5, uncorrected) within about 50 minutes. The specific activity was 14.5 GBq/μmol, and the radiochemical purity was more than 95%. 18F-FHex-β-Glu was synthesized using the precursor 12 based on 18F-F? with the yield of 11 ± 3% (n = 3, uncorrected) in about 60 minutes. The specific activity was 9.1 GBq/μmol, and the radiochemical purity was more than 95%.
