53878-96-9

Basic information

• Product Name: 1,4-diamino-2-butyne
• Synonyms: 1,4-diamino-2-butyne;2-Butyne-1,4-diaMine
• CAS NO: 53878-96-9
• Molecular Formula: C₄H₈N₂
• Molecular Weight: 84.1197
• Mol File: 53878-96-9.mol
• Article Data: 9

Chemical Properties

• Melting Point: 44°C
• Boiling Point: 144.44°C (rough estimate)
• Flash Point: 84.3 °C
• Appearance: /
• Density: 0.8698 (rough estimate)
• Vapor Pressure: 0.374mmHg at 25°C
• Refractive Index: 1.4449 (estimate)
• CAS DataBase Reference: 1,4-diamino-2-butyne(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4-diamino-2-butyne(53878-96-9)
• EPA Substance Registry System: 1,4-diamino-2-butyne(53878-96-9)

Safety Data

• Hazardous Substances Data: 53878-96-9(Hazardous Substances Data)

Usage

General Description

1,4-diamino-2-butyne, also known as DAB or diaminobutyne, is a chemical compound with the molecular formula C4H8N2. It is a highly reactive compound that contains two amino groups and a triple bond between two carbon atoms. DAB is often used as a building block in the synthesis of various organic compounds, including pharmaceuticals, dyes, and polymers. It is also used as a reagent in chemical reactions, such as in the formation of heterocycles and organic frameworks. However, DAB is highly combustible and must be handled with care due to its potential for explosive reactions. Overall, 1,4-diamino-2-butyne is an important chemical with versatile applications in organic synthesis and the production of various industrial products.

InChI:InChI=1/C4H8N2/c5-3-1-2-4-6/h3-6H2

Upstream product

• 2917-96-6 1,4-bis(methanesulfonyloxy)-2-butyne 
• 627-37-2 N-methyl-N-allylamine 
• 50-00-0 formaldehyd 
• 111-92-2 dibutylamine 
• 471-25-0 Propiolic acid 
• 142-84-7 di-n-propylamine 
• 91686-83-8 1,4-diazido-2-butyne 
• 110-65-6 1,4-dihydroxybut-2-yne 
• 821-10-3 1,4-Dichloro-2-butyne 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 675605-47-7 (4-amino-but-2-ynyl)-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of a glycosylated ortho-carboranyl amino acid

The preparation of an ortho-carborane derivative bearing both carbohydrate and amino acid substituents is presented; opening of a glucofuranuro-γ-lactone derivative with propargylamines, cycloaddition of decaborane to an acetylenic bond and amidation with a N-Fmoc-glutamate derivative are the key-steps in this synthesis.

Bis(amino acid) derivatives of 1,4-diamino-2-butyne that adopt a C 2-symmetric turn conformation

1,4-Diamino-2-butyne was prepared from 1,4-dichloro-2-butyne via 1,4-diazido-2-butyne. Bis(amino acid) derivatives of 1,4-diamino-2-butyne having the general structure (Boc-Xxx-NHCH2C≡)2 (Xxx = Ala, Phe and Met) were prepared and examined by 1H NMR spectroscopy. Using chemical shift, coupling constant and DMSO titration data it is found that these compounds adopt a C2-symmetric turn conformation featuring two intramolecular hydrogen bonds. The Royal Society of Chemistry 2005.

DIAMINE CALCIUM CHANNEL BLOCKERS

Aromatic derivatives of aliphatic diamines are effective in ameliorating conditions characterized by unwanted calcium ion channel activity, especially T-type and N-type channels. These conditions include, for example, stroke and pain. The aromatic derivat