540-61-4

Basic information

• Product Name: AMINOACETONITRILE
• Synonyms: AMINOACETONITRILE;Glycinonitrile;2-Aminoacetonitrile;Acetonitrile, amino-;alpha-Aminoacetonitrile;amino-acetonitril;aminoacetonitrilefreebase;Cyanomethylamine
• CAS NO: 540-61-4
• Molecular Formula: C₂H₄N₂
• Molecular Weight: 56.07
• EINECS: 208-751-8
• Mol File: 540-61-4.mol
• Article Data: 22

Chemical Properties

• Melting Point: 101 °C
• Boiling Point: bp15 58° (partial decompn)
• Flash Point: 53.1°C
• Appearance: /
• Density: 0.7789 (rough estimate)
• Vapor Pressure: 1.99mmHg at 25°C
• Refractive Index: 1.4180 (estimate)
• Storage Temp.: −20°C
• PKA: 5.34(at 25℃)
• CAS DataBase Reference: AMINOACETONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: AMINOACETONITRILE(540-61-4)
• EPA Substance Registry System: AMINOACETONITRILE(540-61-4)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 23-36
• RIDADR: NA 1993 / PGIII
• WGK Germany: 3
• RTECS: AL7750000
• Hazardous Substances Data: 540-61-4(Hazardous Substances Data)

Usage

Description

Aminoacetonitrile, also known as 2-aminoacetonitrile or α-aminoacetonitrile, is an organic compound with the chemical formula CH3CH(NH2)CN. It is a colorless, toxic liquid that is soluble in water and has a variety of applications in the chemical and pharmaceutical industries due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
Aminoacetonitrile is used as an intermediate in the synthesis of various heterocyclic compounds, which have significant medical applications. These heterocyclic compounds are often the core structures of many pharmaceutical drugs, making Aminoacetonitrile a crucial component in the development of new medications.
Used in Chemical Industry:
In the chemical industry, Aminoacetonitrile is utilized as a building block for the production of various organic compounds, such as amino acids, peptides, and other nitrogen-containing molecules. Its versatility in chemical reactions allows it to be a valuable asset in the synthesis of a wide range of products.

InChI:InChI=1/C2H4N2/c3-1-2-4/h1,3H2

Upstream product

• 107-14-2 chloroacetonitrile 
• 107-16-4 glycolonitrile 
• 34557-54-5 methane 
• 79-01-6 Trichloroethylene 
• 109-82-0 methyleneaminoacetonitrile 
• 50-00-0 formaldehyd 
• 74-90-8 hydrogen cyanide 
• 75-86-5 2-hydroxy-2-methylpropanenitrile 
• 598-41-4 H-Gly-NH₂ 
• 107-15-3 ethylenediamine 
• 6011-14-9 2-aminoacetonitrile hydrochloride 
• 85363-04-8 tert-butyl cyanomethylcarbamate 
• 7664-41-7 ammonia 
• 100-97-0 hexamethylenetetramine 

Downstream Products

• 99361-25-8 5-benzylidenamino-3H-thiazol-2-one 
• 34039-84-4 α-(benzylideneamino)acetonitrile 
• 3589-41-1 phenylmethyl cyanomethylcarbamate 
• 628-87-5 iminodiacetonitrile 
• 22198-18-1 N-(2-chloro-benzoyl)-glycine nitrile 
• 22198-19-2 4-chlorobenzoylaminoacetonitrile 
• 40699-31-8 2-(m-methoxybenzamido)-ethanenitrile 
• 99488-29-6 4-(2-Hydroxy-5-methoxy-benzoyl)-6-(6-methoxy-4-oxo-4H-chromen-3-yl)-pyridine-2-carbonitrile 
• 87783-69-5 (2E)-N-(cyanomethyl)-3-phenylacrylamide 
• 107-15-3 ethylenediamine 
• 5962-07-2 cyanomethylurea 
• 26947-41-1 3-cyanoisoquinoline 
• 603139-12-4 (2S)-4-methyl-2-[(1S)-2,2,2-trifluoro-1-(4'-methanesulfonyl-biphenyl-4-yl)ethylamino]-pentanoic acid cyanomethyl-amide 

Relevant articles and documents

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Method for synthesizing aminoacetonitrile hydrochloride from hydrocyanic acid

The invention relates to the technical field of organic chemical synthesis. The method comprises the following steps: reacting hydrocyanic acid with formaldehyde to obtain a hydroxyacetonitrile aqueous solution, reacting hydroxyacetonitrile with ammonia to obtain an aminoacetonitrile aqueous solution, reacting aminoacetonitrile with hydrogen chloride, and concentrating, crystallizing, filtering and drying the obtained feed liquid to obtain aminoacetonitrile hydrochloride. The method provided by the invention is simple in technological process and mild in reaction condition, high-temperature and high-pressure operation is not involved, and used equipment is conventional equipment; except hydrocyanic acid, other raw materials are easy to obtain, and the raw material cost is low; waste waterand waste gas are small in amount and can be used indiscriminately, and only a small amount of ammonium chloride is generated; the product quality is good, and the appearance and content are higher than those of a sodium cyanide process.

New synthesis method of orotic acid

The invention belongs to the field of organic chemistry and discloses a new synthesis method of orotic acid, comprising the following steps: S1: enabling glycolonitrile and ammonia wate to react, thusobtaining a reaction system a in which a product is aminoacetonitrile A; S2: enabling aminoacetonitrile A and cyanate to react, thus obtaining a reaction system b in which a product is cyanomethylurea B; S3: performing condensation-rearrangement on cyanomethylurea B and glyoxylic acid in an alkaline solution to obtain orotic acid I. The method has the advantages of safe operation, low cost, lesspollution from three wastes, total reaction yield of 80% or above, and easy industrialization.