540527-54-6

Basic information

• Product Name: 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine
• Synonyms: 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine
• CAS NO: 540527-54-6
• Molecular Weight: 411.674
• Mol File: 540527-54-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine(540527-54-6)
• EPA Substance Registry System: 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine(540527-54-6)

Safety Data

• Hazardous Substances Data: 540527-54-6(Hazardous Substances Data)

Upstream product

• 7371-94-0 2-[4-(bromomethyl)phenyl]acetonitrile 
• 54722-41-7 1-tetradecyl piperazine 

Downstream Products

• 540527-55-7 1-[4-(N'-hydroxyamidinomethyl)benzyl]-4-tetradecylpiperazine 

Relevant articles and documents

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

Among the different PLA2s identified to date, the group IIA secretory PLA2 (sPLA2 GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 μM). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg).