7371-94-0

Basic information

• Product Name: 2-[4-(broMoMethyl)phenyl]acetonitrile
• Synonyms: 2-[4-(broMoMethyl)phenyl]acetonitrile
• CAS NO: 7371-94-0
• Molecular Formula: C₉H₈BrN
• Molecular Weight: 210.07052
• Mol File: 7371-94-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 305.8±22.0 °C(Predicted)
• Appearance: /
• Density: 1.447±0.06 g/cm3(Predicted)
• CAS DataBase Reference: 2-[4-(broMoMethyl)phenyl]acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[4-(broMoMethyl)phenyl]acetonitrile(7371-94-0)
• EPA Substance Registry System: 2-[4-(broMoMethyl)phenyl]acetonitrile(7371-94-0)

Safety Data

• Hazardous Substances Data: 7371-94-0(Hazardous Substances Data)

Usage

Chemical structure

Phenyl ring with bromomethyl substituent at para position attached to acetonitrile moiety

Common uses

Organic synthesis, pharmaceutical research

Role

Building block for synthesis of pharmaceuticals, agrochemicals, fine chemicals

Properties

Versatile, valuable, intermediate in production of diverse compounds

Hazards

Requires proper handling due to potential hazards

Handling

Should only be used and handled by trained professionals in controlled laboratory setting

Upstream product

• 2947-61-7 (4-methylphenyl)acetonitrile 
• 50685-26-2 4-(cyanomethyl)benzoic acid 
• 144825-18-3 4-cyanomethylbenzyl alcohol 

Downstream Products

• 1017275-77-2 [4-(4-methyl-piperazin-1-ylmethyl)-phenyl]-acetonitrile 
• 669002-19-1 (4-pyrrolidin-1-ylmethyl-phenyl)-acetonitrile 
• 132312-25-5 (4-dimethylaminomethyl-phenyl)-acetonitrile 
• 1229612-75-2 1-(4-cyanomethylbenzyl)-4-(4-tetradecyloxyphenyl)piperazine 
• 1229612-76-3 1-(4-cyanomethylbenzyl)-4-(4-octadecyloxyphenyl)piperazine 
• 407623-60-3 4-(4-chlorobenzoyl)-1-(4-cyanomethylbenzyl)-1,3,4,5-tetrahydrobenzo[e][1,4]diazepin-2-on 
• 669002-63-5 (4-diethylaminomethyl-phenyl)-acetonitrile 
• 540527-54-6 1-(4-cyanomethylbenzyl)-4-tetradecylpiperazine 
• 184879-24-1 3-{4-[2-(5-Chloro-2-methoxy-benzoylamino)-ethyl]-phenyl}-2-(4-isopropyl-phenoxy)-2-methyl-propionic acid ethyl ester 
• 184879-23-0 3-[4-(2-Amino-ethyl)-phenyl]-2-(4-isopropyl-phenoxy)-2-methyl-propionic acid ethyl ester 

Relevant articles and documents

OXADIAZOLES AS FUNGICIDES

The present invention relates to novel oxadiazoles of Formula (I) wherein, R1, L1, A1, A2, A3, A4, L2 and R2 are as defined in the detailed description. The present in

Design of new potent and selective secretory phospholipase A2 inhibitors. Part 5: Synthesis and biological activity of 1-alkyl-4-[4,5-dihydro-1,2,4-[4H]-oxadiazol-5-one-3-ylmethylbenz-4′-yl(oyl)] piperazines

Among the different PLA2s identified to date, the group IIA secretory PLA2 (sPLA2 GIIA) is implied in diverse pathological conditions. In this work we describe the synthesis, inhibitory activities, and structure-activity relationships (SAR) of a new class of substituted piperazine derivatives. The in vitro fluorimetric assay using two groups of enzymes, GIB and GIIA, revealed several compounds as highly potent inhibitors (IC50 = 0.1 μM). The in vivo activity assessed by ip or per os administration in a carrageenan-induced edema test in rats showed that two compounds proved to be as potent as indomethacin (10 mg/kg).

NOVEL AMIDE COMPOUNDS WITH MCH ANTAGONISTIC EFFECT AND MEDICAMENTS COMPRISING SAID COMPOUNDS

The invention relates to amide compounds of general formula (I), in which the groups and residues A, B, b, W, X, Y, Z, R1, R2 and R3 have the meanings given in claim 1. The invention further relates to medicaments comprising at least one of said amides. Said medicaments are suitable for the treatment of metabolic disorders and/or eating disorders, in particular, obesity, bulimia, anorexia, hyperphagia, and diabetes as a result of the MCH receptor antagonism.