5406-18-8

Basic information

• Product Name: 3-(4-METHOXYPHENYL)-1-PROPANOL
• Synonyms: 3-(4-Methoxyphenyl)propane-1-ol;3-(4-Methoxyphenyl)propyl alcohol;4-Methoxybenzene-1-propanol;3-(4-Methoxyphenyl)-1-propanol ,98%;3-(4-Methoxyphenyl)-1-propanol 99%;4-methoxyphenylpropanol;NSC 5311;3-(P-METHOXYPHENYL)PROPANOL
• CAS NO: 5406-18-8
• Molecular Formula: C₁₀H₁₄O₂
• Molecular Weight: 166.22
• EINECS: 226-463-0
• Product Categories: C9 to C30;Oxygen Compounds;Building Blocks;C9 to C10;Chemical Synthesis;Organic Building Blocks;Oxygen Compounds;Alcohols
• Mol File: 5406-18-8.mol
• Article Data: 73

Chemical Properties

• Melting Point: 26 °C(lit.)
• Boiling Point: 164-168 °C18 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.0060 (rough estimate)
• Vapor Pressure: 0.00145mmHg at 25°C
• Refractive Index: n20/D 1.532(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 15.08±0.10(Predicted)
• CAS DataBase Reference: 3-(4-METHOXYPHENYL)-1-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHOXYPHENYL)-1-PROPANOL(5406-18-8)
• EPA Substance Registry System: 3-(4-METHOXYPHENYL)-1-PROPANOL(5406-18-8)

Safety Data

• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 5406-18-8(Hazardous Substances Data)

Usage

Description

3-(4-Methoxyphenyl)-1-propanol is an organic compound that is involved in the β-alkylation of 1-phenylethanol, a process catalyzed by RuCl2(DMSO)4. 3-(4-METHOXYPHENYL)-1-PROPANOL is characterized by its unique chemical structure, which features a propanol backbone with a 4-methoxyphenyl group attached to the third carbon.

Uses

Used in Chemical Synthesis:
3-(4-Methoxyphenyl)-1-propanol is used as an intermediate in the synthesis of various organic compounds. Its unique structure allows it to participate in β-alkylation reactions, which are crucial for the formation of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 3-(4-Methoxyphenyl)-1-propanol is used as a building block for the development of new drugs. Its ability to undergo β-alkylation reactions makes it a valuable component in the synthesis of novel pharmaceutical compounds with potential therapeutic applications.
Used in Flavor and Fragrance Industry:
3-(4-Methoxyphenyl)-1-propanol, due to its unique aromatic characteristics, can be used as a component in the creation of various flavors and fragrances. Its distinct chemical structure contributes to the development of new and innovative scents for the perfume and aromatherapy markets.
Used in Material Science:
In material science, 3-(4-Methoxyphenyl)-1-propanol can be utilized in the development of new materials with specific properties. Its participation in β-alkylation reactions can lead to the creation of novel polymers and other materials with unique characteristics, such as enhanced strength, flexibility, or chemical resistance.

InChI:InChI=1/C10H14O2/c1-12-10-6-4-9(5-7-10)3-2-8-11/h4-7,11H,2-3,8H2,1H3

Upstream product

• 64-17-5 ethanol 
• 24393-56-4 ethyl (E)-3-(4-methoxyphenyl)prop-2-enoate 
• 22767-72-2 ethyl 3-(4-methoxyphenyl)propanoate 
• 25413-27-8 3-(4-methoxy-phenyl)propionamide 
• 123-51-3 i-Amyl alcohol 
• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 6267-37-4 1-(3-bromopropoxy)-4-methoxybenzene 
• 74882-10-3 4-(2,3,4-trimethoxyphenyl)-1-bromobutane 
• 142834-89-7 3-(4-Methoxy-phenyl)-propionic acid 2,3-dichloro-5,6-dicyano-4-[3-(4-methoxy-phenyl)-propionyloxy]-phenyl ester 
• 24393-56-4 ethyl p-methoxycinnamate 
• 51686-51-2 methyl 4-(2,3,4-trimethoxyphenyl)butanoate 
• 51686-50-1 methyl 3-(2,3,4-trimethoxybenzoyl)propionate 
• 75-21-8 oxirane 
• 74260-40-5 4-methoxybenzyltri-n-butylstannane 

Downstream Products

• 5597-61-5 4-(3-Hydroxypropyl)-cyclohexen-3-on 
• 88537-43-3 1-p-toluenesulfonyloxy-3-(4-methoxyphenyl)propane 
• 3875-77-2 7-methoxychroman 
• 22442-48-4 3-(4-methoxyphenyl)propionitrile 
• 36397-23-6 3-(4-methoxyphenyl)propylamine 
• 952315-65-0 (E)-6-(4-methoxyphenyl)hex-3-en-2-one 
• 88537-44-4 3-(4-methoxyphenyl)propane-1-thiol 
• 135981-59-8 4-but-3-enyl-phenol 
• 310465-53-3 1-[3-(4-Methoxy-phenyl)-propyl]4-thiophen-3-yl-1H-imidazole 
• 130209-93-7 3-(4-methoxyphenyl)-1-propanol nitrate 
• 1267970-83-1 4-((2-(4-(4-methoxybenzyl)thiazol-2-yl)hydrazono)methyl)benzene-1,3-diol 
• 1338496-30-2 3-(4-methoxyphenyl)propyl 2-acetamido-2-deoxy-β-D-glucopyranoside 
• 1334539-00-2 2-(4-methoxybenzyl)-5-(4-methoxyphenyl)pentan-1-ol 
• 4877-10-5 1,5-bis(4-methoxyphenyl)pentane 

Relevant articles and documents

Highly Stereoselective Synthesis of Fused Tetrahydropyrans via Lewis-Acid-Promoted Double C(sp3)-H Bond Functionalization

We have achieved a sequential hydride-shift-triggered double C(sp3)-H bond functionalization at a position adjacent to an oxygen atom and a benzylic/aliphatic position through the employment of substrates with a dialkyl group in the alkyl chain, which enabled the highly diastereoselective synthesis of fused tetrahydropyrans.

Access to Trisubstituted Fluoroalkenes by Ruthenium-Catalyzed Cross-Metathesis

Although the olefin metathesis reaction is a well-known and powerful strategy to get alkenes, this reaction remained highly challenging with fluororalkenes, especially the Cross-Metathesis (CM) process. Our thought was to find an easy accessible, convenient, reactive and post-functionalizable source of fluoroalkene, that we found as the methyl 2-fluoroacrylate. We reported herein the efficient ruthenium-catalyzed CM reaction of various terminal and internal alkenes with methyl 2-fluoroacrylate giving access, for the first time, to trisubstituted fluoroalkenes stereoselectively. Unprecedent TON for CM involving fluoroalkene, up to 175, have been obtained and the reaction proved to be tolerant and effective with a large range of olefin partners giving fair to high yields in metathesis products. (Figure presented.).

A General Method for Photocatalytic Decarboxylative Hydroxylation of Carboxylic Acids

A general and practical method for decarboxylative hydroxylation of carboxylic acids was developed through visible light-induced photocatalysis using molecular oxygen as the green oxidant. The addition of NaBH4 to in situ reduce the unstable peroxyl radical intermediate much broadened the substrate scope. Different sp3 carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids. This transformation worked smoothly on primary, secondary, and tertiary carboxylic acids.