541-23-1

Basic information

• Product Name: 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE
• Synonyms: 3-methyl-1-butanaminhydrochloride;3-Methyl-butyl-ammoniumchloride;isoamylaminehydrochloride;isopentylamine,hydrochloride;Isopentylaminehydrochloride;isopentylammoniumchloride;3-Methylbutan-1-aMine hydrochloride
• CAS NO: 541-23-1
• Molecular Formula: C₅H₁₄N*Cl
• Molecular Weight: 123.62436
• Mol File: 541-23-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 65-69 °C
• Boiling Point: 92.7°Cat760mmHg
• Flash Point: 18.3°C
• Appearance: /
• Density: 0.757g/cm³
• Water Solubility: Soluble in water
• BRN: 3947083
• CAS DataBase Reference: 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE(541-23-1)
• EPA Substance Registry System: 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE(541-23-1)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: NT0200000
• F: 3-10
• Hazardous Substances Data: 541-23-1(Hazardous Substances Data)

Usage

Description

1-AMINO-3-METHYLBUTANE HYDROCHLORIDE, also known as N-Methylbutylamine hydrochloride, is a chemical compound with the molecular formula C5H13N. It is a hydrochloride salt of a primary amine and is commonly used as a pharmaceutical intermediate and in organic synthesis. 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is an important chemical precursor for the production of various drugs and can also function as a reactant in the synthesis of other organic compounds.

Uses

Used in Pharmaceutical Industry:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as a pharmaceutical intermediate for the production of various drugs. It plays a crucial role in the synthesis of medicinal compounds, contributing to the development of new pharmaceuticals.
Used in Organic Synthesis:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as a reactant in organic synthesis, enabling the creation of a wide range of organic compounds for various applications.
Used in Agrochemical Production:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as an intermediate in the manufacture of agrochemicals, contributing to the development of products that support agricultural processes and crop protection.
Used in Food Additive Industry:
1-AMINO-3-METHYLBUTANE HYDROCHLORIDE is used as an intermediate in the production of food additives, playing a role in enhancing the quality, taste, or preservation of food products.
It is important to handle 1-AMINO-3-METHYLBUTANE HYDROCHLORIDE with caution due to its corrosive nature, as it can cause irritation to the skin, eyes, and respiratory system if not handled properly.

InChI:InChI=1/C5H13N.ClH/c1-5(2)3-4-6;/h5H,3-4,6H2,1-2H3;1H

Upstream product

• 627-67-8 1-nitro-3-methylbutane 
• 541-46-8 isobutylamide 
• 625-28-5 Isovaleronitrile 
• 107-85-7 1-amino-3-methylbutane 
• 590-86-3 isovaleraldehyde 
• 250650-58-9 N-diphenylmethyl-3-methyl-butylamine 
• 51411-34-8 Benzhydrylidene-(3-methyl-butyl)-amine 
• 2695-37-6 sodium 4-styrenesulfonate 

Downstream Products

• 1583283-69-5 C₂₁H₃₆N₃O₅P 
• 1583283-24-2 (S)-2-((N-(benzyloxycarbonyl)aminomethylphosphonyl)amino)-N-isopentyl-4-methylpentanamide lithium 
• 147972-14-3 4'-[[[2-[(3-methylbutyl)amino]-4-quinazolinyl]amino]methyl][1,1'-biphenyl]-2-carboxylic acid methyl ester 
• 84851-37-6 (S)-1-(isopentylamino)-2-amino-4-methyl-1-oxopentan hydrochloride 
• 84863-67-2 (S)-t-butyl 1-(isopentylamino)-4-methyl-1-oxopentan-2-ylcarbamate 
• 578-20-1 Egressin 

Relevant articles and documents

Selective Hydrogenation of Nitriles to Primary Amines Catalyzed by a Polysilane/SiO2-Supported Palladium Catalyst under Continuous-Flow Conditions

Hydrogenation of nitriles to primary amines with heterogeneous catalysts under liquid-phase continuous-flow conditions is described. Newly developed polysilane/SiO2-supported Pd was found to be an effective catalyst and various nitriles were converted into primary amine salts in almost quantitative yields under mild reaction conditions. Interestingly, a complex mixture was obtained under batch conditions. Lifetime experiments showed that this catalyst remained active for more than 300 h (TON≥10 000) without loss of selectivity and no metal leaching from the catalyst occurred. By using this continuous-flow hydrogenation, synthesis of venlafaxine, an antidepressant drug, has been accomplished.

Hydrogenation of Aliphatic and Aromatic Nitriles Using a Defined Ruthenium PNP Pincer Catalyst

Selective catalytic reductions of nitriles are presented using the commercially available Ru-Macho-BH complex. A variety of aliphatic, aromatic and (hetero)cyclic nitriles including industrially important adipodinitrile are hydrogenated to the corresponding primary amines. Modelling suggests the reaction follows an outer sphere hydrogenation mechanism. An efficient and selective catalytic reduction of nitriles is presented using the commercially available Ru-Macho-BH complex. A variety of aliphatic, aromatic and (hetero)cyclic nitriles including the industrially important adipodinitrile are hydrogenated to the corresponding primary amines. The reaction follows an outer-sphere mechanism.

A practical procedure for reduction of primary, secondary and tertiary amides to amines

A mild and general procedure for reduction of primary, secondary, and tertiary amides using catalytic triruthenium dodecacarbonyl and 1,1,3,3-tetramethyldisiloxane as reductant is described. The reaction is tolerant of numerous functional groups, and the amine products can often be isolated by direct crystallization as hydrochloride salts. The catalyst and silane are commercially available, air stable, and inexpensive, making the procedure accessible for both laboratory and large-scale applications. Copyright