542-56-3Relevant articles and documents
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Plummer,Drake
, p. 2720 (1954)
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Preparation method of 4-(BOC-amino)-1-butanol
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Paragraph 0051; 0053; 0058; 0060; 0065; 0067, (2021/01/28)
The invention discloses a preparation method of 4-(BOC-amino)-1-butanol. The method comprises the following steps: reacting a proper amount of 2, 3-dihydrofuran with an acidic solution to obtain 2, 3-dihydro-5-methyl furan; mixing the obtained 2, 3-dihydro-5-methyl furan with hydrochloride, and then adding the mixture into an alkaline solution for reaction to obtain isobutyl nitrite; reacting isobutyl nitrite under the action of a reducing agent to generate 4-amino-1-butyl alcohol; and reacting 4-amino-1-butyl alcohol with di-tert-butyl dicarbonate in tetrahydrofuran to generate 4-(BOC-amino)-1-butyl alcohol; according to the preparation method of the 4-(BOC-amino)-1-butanol, the total yield of the product is as high as 70%, the reaction temperature is low, and the safety coefficient is high), the reducing agent is cheaper than that in the prior art, the experimental operation method is simple, the steps are short, and the method is suitable for large-scale production.
Reaction of alcohol with NO2 on a Cleaned Glass Surface
Maeda, Yasuaki,Fujio, Yoshifumi,Munemori, Makoto
, p. 2127 - 2130 (2007/10/02)
Formation of alkyl nitrite from alcohol and NO2 was very fast on a Pyrex glass surface cleaned with chromic acid mixture.The reaction was practically zero order with respect to NO2.The rate constant was (1.7 +/- 0.08)*10E-18 cm3*molecule-1*s-1 for methyl nitrile formation and the apparent activation energy was -53.5 kJ*mol-1.
A kinetic study of the influence of alcohols on the nitrosation of morpholine in acid media. Equilibrium constants for the formation of alkyl nitrites
Casado, Julio,Lorenzo, Francisco Manuel,Mosquera, Manuel,Prieto, Maria Flor Rodriguez
, p. 136 - 138 (2007/10/02)
The effect of the aliphatic alcohols methanol, ethanol, propanol, isopropanol, 2-butanol, isobutanol, and tert-butanol on the rate of nitrosation of morpholine at pH 3 and 25 deg C has been studied.The inhibition observed is attributed to the formation of alkyl nitrites, which are poor nitrosating agents in acid media.The equilibrium constants for the formation of alkyl nitrites from nitrous acid and alcohols have been calculated both spectrophotometrically and from kinetic data for the inhibitory effect, and there is agreement between the two sets of results.The molar absorptivities at 265 nm of the alkyl nitrites have also been determined.When the concentration of alkyl nitrite is very low, a slight catalytic effect considered to be an effect of the medium has been observed.