54231-38-8

Basic information

• Product Name: 3-BROMO-2-(4-MORPHOLINO)PYRIDINE
• Synonyms: 3-BROMO-2-(4-MORPHOLINO)PYRIDINE;3-bromo-2-morpholinopyridine;4-(3-broMopyridin-2-yl)Morpholine;Morpholine, 4-(3-bromo-2-pyridinyl)-
• CAS NO: 54231-38-8
• Molecular Formula: C9H11BrN2O
• Molecular Weight: 243.1
• Product Categories: Organohalides;Pyridine
• Mol File: 54231-38-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 94-95 °C
• Boiling Point: 337.1±42.0 °C(Predicted)
• Appearance: /
• Density: 1.499±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 3.21±0.10(Predicted)
• CAS DataBase Reference: 3-BROMO-2-(4-MORPHOLINO)PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMO-2-(4-MORPHOLINO)PYRIDINE(54231-38-8)
• EPA Substance Registry System: 3-BROMO-2-(4-MORPHOLINO)PYRIDINE(54231-38-8)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 54231-38-8(Hazardous Substances Data)

Usage

General Description

3-BROMO-2-(4-MORPHOLINO)PYRIDINE is a chemical compound with the molecular formula C9H10BrN2O. It is a pyridine derivative with a bromo substituent at position 3 and a morpholino group at position 2. 3-BROMO-2-(4-MORPHOLINO)PYRIDINE has applications in medicinal chemistry and pharmaceutical research, particularly in the development of potential drug candidates targeting specific biological pathways. Its unique structure and properties make it a valuable building block for the synthesis of various bioactive molecules. The presence of the morpholino group also contributes to its potential as a pharmacologically active compound. Overall, 3-BROMO-2-(4-MORPHOLINO)PYRIDINE holds promise as a versatile and important chemical in the field of drug discovery and development.

Upstream product

• 110-91-8 morpholine 
• 54231-33-3 3-bromo-2-nitropyridine 
• 626-55-1 3-Bromopyridine 
• 5765-65-1 4-(benzoyloxy)morpholine 
• 52200-48-3 3-bromo-2-chloropyridine 

Relevant articles and documents

Developing backbone-modified Mor-DalPhos ligand variants for use in palladium-catalyzed C-N and C-C cross-coupling

The present contribution describes the systematic structural diversification of the ?°2-P,N DalPhos ligand family in an effort to improve catalytic efficiency in the monoarylation of ammonia and acetone. The study is focused primarily on modifying the backbone phenylene linker, while retaining the same bite angle and steric bulk as the Mor-DalPhos ligand through the use of P(1-Ad)2 and morpholine donors. Eight new variants of Mor-DalPhos were prepared; two of these feature a pyridine linker (L1, L2), and five others feature either electron-donating (L3, L4) or electron-withdrawing (L5-L7) substituents on the phenylene linker. Additionally, thiomorpholino substitution (L8) was performed to investigate the effects of a possible tridentate coordination mode. Precatalyst complexes of the general formula LPd(cinnamyl)Cl were prepared and characterized in both solution and solid state. Solution studies demonstrated a significant degree of lability in the Pd-N bond, whereby dynamic behavior is seen to be dependent on the nature of the ligand backbone. The utility of these new ligands in the palladium-catalyzed monoarylation of ammonia or acetone was then surveyed. Notably, pyridine-derived ligand variants (L1, L2) were observed to out-perform parent Mor-DalPhos in the latter transformations.

Copper-catalyzed electrophilic amination of heteroarenes and arenes by C-H zincation

Direct amination of heteroarenes and arenes has been achieved in a one-pot C-H zincation/copper-catalyzed electrophilic amination procedure. This amination method provides an efficient and rapid approach to access a diverse range of heteroaromatic and aromatic amines including those previously inaccessible using C-H amination methods. The mild reaction conditions and good functional-group compatibility demonstrate its great potential for the synthesis of important and complex amines. Direct amination of heteroarenes and arenes has been achieved in a one-pot zincation/Cu(OAc)2-catalyzed amination sequence using O-acylhydroxylamines. The method provides a rapid and efficient approach to a range of aromatic and heteroaromatic amines, including those which were previously inaccessible by using C-H amination methods. tmp=2,2,6,6- tetramethylpiperidide.