54239-37-1

Basic information

• Product Name: CIMATEROL
• Synonyms: 2-AMINO-5-[1-HYDROXY-2-[(1-METHYLETHYL)AMINO]ETHYL]BENZONITRILE;CIMATEROL;CIMETEROL;CL-263780;CiMater;cimaterol Solution, 100ppm
• CAS NO: 54239-37-1
• Molecular Formula: C₁₂H₁₇N₃O
• Molecular Weight: 219.28
• Product Categories: Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 54239-37-1.mol
• Article Data: 8

Chemical Properties

• Melting Point: 162-164?C
• Boiling Point: 436.6°C at 760 mmHg
• Flash Point: 217.8°C
• Appearance: /
• Density: 1.14g/cm³
• Vapor Pressure: 2.15E-08mmHg at 25°C
• Refractive Index: 1.573
• Storage Temp.: Store at RT
• Solubility: Soluble in ethanol or DMSO
• PKA: 13.75±0.20(Predicted)
• BRN: 2418129
• CAS DataBase Reference: CIMATEROL(CAS DataBase Reference)
• NIST Chemistry Reference: CIMATEROL(54239-37-1)
• EPA Substance Registry System: CIMATEROL(54239-37-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37
• WGK Germany: 3
• RTECS: DI2457930
• Hazardous Substances Data: 54239-37-1(Hazardous Substances Data)

Usage

Chemical Properties

Off-White Solid

Uses

Different sources of media describe the Uses of 54239-37-1 differently. You can refer to the following data:
1. A β-adrenergic agonist, related to Clenbuterol and Mabuterol. A repartitioning agent.
2. antiasthmatic
3. A beta-adrenergic agonist

Biological Activity

β -Adrenergic agonist.

InChI:InChI=1/C12H17N3O/c1-8(2)15-7-12(16)9-3-4-11(14)10(5-9)6-13/h3-5,8,12,15-16H,7,14H2,1-2H3

Upstream product

• 56759-32-1 1-(4-amino-3-bromophenyl)-ethanone 
• 99-92-3 p-aminobenzophenone 
• 54239-38-2 1-(4'-Amino-3'-bromo-5'-cyano-phenyl)-2-isopropylamino-ethanol 
• 75-31-0 isopropylamine 
• 88167-50-4 3-cyano-4-aminophenyl bromomethyl ketone 
• 33720-71-7 4-amino-3-cyanoacetophenone 
• 54239-57-5 l-(4-amino-3-chloro-5-cyanophenyl)-2-isopropylaminoethanol hydrochloride 

Downstream Products

• 912804-59-2 C₁₂H₁₇N₃O 

Relevant articles and documents

Phenylethanolamine β receptor agonist synthetic method

The invention discloses a phenylethanolamine β receptor agonist synthetic method, comprises the following steps: S1: the 4 - amino acetophenone dissolved in an organic solvent, with the electrophilic reagent occurs on the benzene ring substituted halogenated reaction, generating [...] intermediate; [...] intermediates in organic solvent or in water, under the catalysis of the metal catalyst with the cyanide reagent undergo nucleophilic substitution reaction, generating phenyl ketone intermediate; S2: phenyl ketone intermediates in organic solvent, with the copper bromide generating carbonyl α bromo reaction to produce α - bromoacetophenone intermediates; S3: α - bromoacetophenone intermediates in organic solvent with tert-butyl amine or isopropylamine reaction intermediates acetophenone amines; S4: acetophenone amine intermediates in organic solvent, with the reduction hydrogenation reagent react to generate the phenylethanolamine β receptor agonists; synthetic method of this invention a simple and highly efficient and cheap and easy to obtain, atom utilization is high, the synthetic product chemical purity is greater than 99%, to meet the detection requirements of the food safety.

Separation of enantiomers of cimaterol, (-)-cimaterol and the use thereof in animal feeds

The invention relates to the separation of enantiomers, of cimaterol, (-)-cimaterol, the addition salts thereof and processes for preparing them and their use in pharmaceutical compositions and animal feeds.

Method for increasing weight gains and reducing deposition of fat in animals

The invention is a novel method comprising administering growth hormones parenterally and substituted phenylethane derivatives orally or parenterally to meat producing animals to obtain increased weight gains and anti-lipogenic activity in the animals.