54311-89-6Relevant articles and documents
'Counter-intuitive' regioselectivity, subtle steric and solvation effects in lithiation of cyclic tertiary aralkylamines
Kessar, Satinder V.,Singh, Paramjit,Singh, Kamal Nain,Venugopalan,Kaur, Amarjit,Mahendru, Manu,Kapoor, Rajiv
, p. 6753 - 6755 (2005)
Lithiation of a series of cyclic aralkyl tertiary amines with sec-BuLi in various solvents has been studied. There is a subtle sensitivity to steric factors and lithium coordinating solvents/additives have an adverse effect. ortho-Lithiation is observed only in the case of an eight-membered cyclic amine and the ease of benzylic lithiation with respect to nitrogen is in the surprising order γ > β ? α, δ. These observations are discussed in the context of nitrogen coordination promoted lithiation.
A de novo synthetic method to the access of N-substituted benzazepines
Ouchakour, Lamiaa,Nonn, Melinda,D'hooghe, Matthias,Kiss, Loránd
supporting information, (2020/02/04)
A novel, convenient procedure has been described for the construction of fluorine-containing benzazepines. The synthetic protocol starting from readily available dihydronaphthalene regioisomers is based on oxidative ring olefin bond cleavage followed by r